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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Kinch, Lisa N. Tagliabracci, Vincent S. Sreelatha, Anju |
| Description | Author Affiliation: Sreelatha A ( Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.); Kinch LN ( Department of Biochemistry, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.); Tagliabracci VS ( Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA. Electronic address: Vincent.tagliabracci@UTSouthwestern.edu.) |
| Abstract | Protein phosphorylation is a nearly universal post-translation modification involved in a plethora of cellular events. Even though phosphorylation of extracellular proteins had been observed, the identity of the kinases that phosphorylate secreted proteins remained a mystery until only recently. Advances in genome sequencing and genetic studies have paved the way for the discovery of a new class of kinases that localize within the endoplasmic reticulum, Golgi apparatus and the extracellular space. These novel kinases phosphorylate proteins and proteoglycans in the secretory pathway and appear to regulate various extracellular processes. Mutations in these kinases cause human disease, thus underscoring the biological importance of phosphorylation within the secretory pathway. This article is part of a Special Issue entitled: Inhibitors of Protein Kinases. |
| ISSN | 00063002 |
| Journal | Biochimica et Biophysica Acta (BBA) - Reviews on Cancer |
| Part | Pt B |
| Issue Number | 10 |
| Volume Number | 1854 |
| Language | English |
| Publisher | Elsevier |
| Publisher Date | 2015-10-01 |
| Publisher Place | Netherlands |
| Access Restriction | Open |
| Subject Keyword | Abnormalities, Multiple Genetics Casein Kinase I Cleft Palate Exophthalmos Extracellular Matrix Proteins Microcephaly Osteosclerosis Protein-Tyrosine Kinases Secretory Pathway Enzymology Animals Chemistry Metabolism Endoplasmic Reticulum Golgi Apparatus Mutation Phosphorylation Protein Conformation Substrate Specificity Research Support, N.I.H., Extramural Biochemistry |
| Content Type | Text |
| Resource Type | Article |
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