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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Pesce, Giuseppe Piccoli, Renata Monti, Daria Maria Del Giudice, Rita Gaglione, Rosa Zito, Gianluigi Arciello, Angela Sasso, Antonio Rusciano, Giulia |
| Description | Author Affiliation: Rusciano G ( Department of Physics E. Pancini, University of Naples Federico II, via Cintia, 80126-I, Naples, Italy. Electronic address: giulia.rusciano@unina.it.); Pesce G ( Department of Physics E. Pancini, University of Naples Federico II, via Cintia, 80126-I, Naples, Italy.); Zito G ( Department of Physics E. Pancini, University of Naples Federico II, via Cintia, 80126-I, Naples, Italy.); Sasso A ( Department of Physics E. Pancini, University of Naples Federico II, via Cintia, 80126-I, Naples, Italy.); Gaglione R ( Department of Chemical Sciences, University of Naples Federico II, via Cintia, 80126-I, Naples, Italy.); Del Giudice R ( Department of Chemical Sciences, University of Naples Federico II, via Cintia, 80126-I, Naples, Italy.); Piccoli R ( Department of Chemical Sciences, University of Naples Federico II, via Cintia, 80126-I, Naples, Italy); Monti DM ( Department of Chemical Sciences, University of Naples Federico II, via Cintia, 80126-I, Naples, Italy); Arciello A ( Department of Chemical Sciences, University of Naples Federico II, via Cintia, 80126-I, Naples, Italy) |
| Abstract | Background About twenty variants of apolipoprotein A-I (ApoA-I) are associated to hereditary systemic amyloidoses. Although the molecular bases of this disease are still largely unknown, it has been hypothesized that ApoA-I proteolysis is a key event in pathogenesis, since it triggers the release of an N-terminal fragment (80–100 residue long) that misfolds to form amyloid deposits in peripheral organs and tissues. It is also known that cell membrane lipids play a key role in the fibrillogenic pathway. In the case of ApoA-I related amyloidosis caused by L174S mutation, the 93-residue N-terminal fragment of ApoA-I ([1-93]ApoA-I) was found to be the major constituent of ex vivo fibrils. |
| ISSN | 00063002 |
| Journal | Biochimica et Biophysica Acta (BBA) - Reviews on Cancer |
| Issue Number | 4 |
| Volume Number | 1860 |
| Language | English |
| Publisher | Elsevier |
| Publisher Date | 2016-04-01 |
| Publisher Place | Netherlands |
| Access Restriction | Open |
| Subject Keyword | 1,2-Dipalmitoylphosphatidylcholine Chemistry Amyloid Apolipoprotein A-I Lipid Bilayers Membranes, Artificial Phosphatidylcholines Metabolism Protein Structure, Tertiary Biochemistry |
| Content Type | Text |
| Resource Type | Article |
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