NDLI: Cell cycle studies of mononucleate and cytochalasin-B--nduced binucleate fibroblasts.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Fournier, R. E. Pardee, A. B.
Abstract	The progress of mononucleate and cytochalasin-B-induced binucleate cells through the G1 period of the growth cycle has been studied. DNA synthesis was initiated in synchrony in both of the nuclei of cells rendered binucleate by a brief pulse of cytochalasin B. Furthermore, populations of these cells traversed the G1 period significantly faster than their mononucleate counterparts. That this effect was due to the presence of two nuclei in a common cytoplasm and not to the increased size of binucleate cells was suggested by studies of cells with altered nucleocytoplasmic ratios. No correlation was observed between protein content per cell and the rate of progress through G1. Evidence for the existence of nuclear-nuclear cooperation that results in a shortening of the G1 period is discussed.
ISSN	00278424
e-ISSN	10916490
Journal	Proceedings of the National Academy of Sciences of the United States of America
Issue Number	3
Volume Number	72
Language	English
Publisher	National Academy of Sciences
Publisher Date	1975-07-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Cell Division Cell Nucleus Cytochalasin B Pharmacology Animals Cell Line Drug Effects Cricetinae DNA Biosynthesis Fibroblasts Hydroxyurea Kidney Kinetics Mitosis Thymidine Metabolism Research Support, U.S. Gov't, P.H.S. Multidisciplinary
Content Type	Text
Resource Type	Article
Subject	Multidisciplinary

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Cell cycle studies of mononucleate and cytochalasin-B--nduced binucleate fibroblasts.