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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Silverman, M. Turner, R. J. |
| Abstract | Uptake studies of simple sugars were performed on a membrane fractions containing osmotically active vesicles prepared from normal human kidney cortex. The uptake of D-glucose was found to be sodium-dependent and phlorizin-sensitive. The specificity of the D-glucose transport mechanism is such that it is shared by alpha-methyl-D-glucoside, D-galactose, and 5-thio-D-glucose, while 2-deoxy-D-glucose, 3-O-methyl-D-glucose, D-mannose, and D-fructose show little, if any, affinity. Measurement of the sodium-dependent component of the initial D-glucose uptake as a function of glucose concentration resulted in a curvilinear Scatchard plot, indicating the possibility of cooperative effects, or alternatively, the existence of two (or more) sodium-dependent D-glucose transporters. In the case of two transporters, we estimate that Km congruent to 0.3 mM and Vmax congruent to 2.5 nmol/min per mg of protein for the 'high-affinity transporter,' and Km approximately 6 mM and Vmax approximately 8 nmol/min per mg of protein for the 'low-affinity transporter.' These specificity and kinetic properties strongly suggest that the sodium-dependent D-glucose transport mechanism characterized in our studies is localized to the brush border of the proximal tubule. |
| ISSN | 00278424 |
| e-ISSN | 10916490 |
| Journal | Proceedings of the National Academy of Sciences of the United States of America |
| Issue Number | 7 |
| Volume Number | 74 |
| Language | English |
| Publisher | National Academy of Sciences |
| Publisher Date | 1977-10-01 |
| Publisher Place | United States |
| Access Restriction | Open |
| Subject Keyword | Hexoses Metabolism Kidney Cortex Adenosine Triphosphatases Alkaline Phosphatase Biological Transport Drug Effects Carrier Proteins Cell Membrane Enzymology Glucose Kidney Tubules, Proximal Kinetics Methylglucosides Phlorhizin Pharmacology Sodium Succinate Dehydrogenase Valinomycin Multidisciplinary |
| Content Type | Text |
| Resource Type | Article |
| Subject | Multidisciplinary |
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