NDLI: Adenylate cyclase and acetylcholine release regulated by separate serotonin receptors of somatic cell hybrids.

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Adenylate cyclase and acetylcholine release regulated by separate serotonin receptors of somatic cell hybrids.

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Adenylate cyclase and acetylcholine release regulated by separate serotonin receptors of somatic cell hybrids.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Macdermot, J. Wilson, S. P. Matsuzawa, H. Minna, J. Higashida, H. Nirenberg, M.
Abstract	Serotonin activates adenylate cyclase [ATP pyrophosphate-lyase (cyclizing), EC 4.6.1.1] of NCB-20 neuroblastoma--brain hybrid cells with an activation constant of 530 nM, but has little or no effect on cellular cyclic AMP or cyclic GMP content of NIE-115 neuroblastoma or NG108-15 hybrid cells. In homogenates of NCB-20 hybrid cells, lysergic acid diethylamide stimulates adenylate cyclase activity (Kact = 12 nM) and partially inhibits (Ki = 10 nM) the stimulation of adenylate cyclase activity by serotonin. No desensitization was detected of serotonin receptors coupled to adenylate cyclase. Serotonin also depolarizes NCB-20, NG108-15, and NIE-115 cells and increases acetylcholine release. Serotonin receptors mediating depolarizing responses desensitize rapidly and reversibly, and the depolarizing effects of serotonin are neither mimicked nor inhibited by lysergic acid diethylamide. These results indicate that (i) NCB-20 cells possess at least two species of serotonin receptors, which independently regulate cellular functions, (ii) activation of adenylate cyclase does not directly affect membrane potential or acetylcholine release, and (iii) serotonin-dependent cell depolarization does not affect cyclic AMP or cyclic GMP synthesis in the cell lines tested.
ISSN	00278424
e-ISSN	10916490
Journal	Proceedings of the National Academy of Sciences of the United States of America
Issue Number	3
Volume Number	76
Language	English
Publisher	National Academy of Sciences
Publisher Date	1979-07-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Acetylcholine Metabolism Adenylate Cyclase Receptors, Serotonin Animals Binding, Competitive Cell Line Cell Transformation, Viral Enzyme Activation Glioma Hybrid Cells Kinetics Lysergic Acid Diethylamide Pharmacology Methysergide Mice Neuroblastoma Parainfluenza Virus 1, Human Serotonin Multidisciplinary
Content Type	Text
Resource Type	Article
Subject	Multidisciplinary

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