NDLI: Cell-Free Desensitization of Opioid Inhibition of Adenylate Cyclase in Neuroblastoma × Glioma NG108-15 Hybrid Cell Membranes

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Cell-Free Desensitization of Opioid Inhibition of Adenylate Cyclase in Neuroblastoma × Glioma NG108-15 Hybrid Cell Membranes

Content Provider	Scilit
Author	Louie, Alan K. Law, Ping-Yee Loh, Horace H.
Copyright Year	2006
Description	Journal: Journal of Neurochemistry When membranes from neuroblastoma X glioma NG108-15 hybrid cells were incubated in a cell-free system with opioid agonists, a time-, temperature-, and dose-dependent desensitization to opioid inhibition of adenylate cyclase activity was observed. The composition of the system during the incubation was manipulated to elucidate the biochemical mechanisms of desensitization. Receptor coupling appeared to be a prerequisite for desensitization, because both magnesium and sodium, which are necessary for coupling, were required for desensitization. Removal of ATP and addition of cyclic AMP or cyclic GMP had no effect on desensitization.
Related Links	http://onlinelibrary.wiley.com/doi/10.1111/j.1471-4159.1986.tb00673.x/pdf
Ending Page	737
Page Count	5
Starting Page	733
e-ISSN	14714159
DOI	10.1111/j.1471-4159.1986.tb00673.x
Journal	Journal of Neurochemistry
Issue Number	3
Volume Number	47
Language	English
Publisher	Wiley-Blackwell
Publisher Date	2006-10-05
Access Restriction	Open
Subject Keyword	Journal: Journal of Neurochemistry Adenylate Cyclase Mx Glioma Hybrid Cells
Content Type	Text
Resource Type	Article

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