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The smallest genome RNA segment of influenza virus contains two genes that may overlap.

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The smallest genome RNA segment of influenza virus contains two genes that may overlap.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Brown, C. M. Barrett, T. Almond, J. W. Inglis, S. C.
Abstract	The genome of influenza virus consists of eight segments of single-stranded RNA, each of which encodes a different polypeptide. In addition to the eight recognized gene products, the virus specifies a distinct smaller nonstructural polypeptide (NS2), which is translated from a separate species of virus-specific mRNA. The location on the virus genome of the gene encoding this polypeptide was investigated by hybridization of the NS2 mRNA with isolated subgenomic RNA species, and by correlation of the inheritance of a strain-specific NS2 with inheritance of particular genome RNA segments during recombination between two different virus strains. The genetic information for NS2 was found to reside in the smallest genome RNA segment of the virion, which also encodes the NS1 polypeptide. Considering the sizes of the molecules involved, it is likely that the coding sequences for the two polypeptides overlap.
ISSN	00278424
e-ISSN	10916490
Journal	Proceedings of the National Academy of Sciences of the United States of America
Issue Number	8
Volume Number	76
Language	English
Publisher	National Academy of Sciences
Publisher Date	1979-12-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Genes, Viral Influenza A Virus Genetics RNA, Viral Viral Proteins Genetic Linkage Molecular Weight Nucleic Acid Hybridization RNA, Messenger Recombination, Genetic Multidisciplinary
Content Type	Text
Resource Type	Article
Subject	Multidisciplinary

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