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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Fairchild, S. S. Cohen, J. J. |
| Abstract | The activity of T lymphocyte precursors (pre-T cells) in the bone marrow of mice was measured by the concanavalin A response synergy assay. Pre-T cell levels were low in marrow of neonatally thymectomized mice and could be restored to control values by treatment in vivo with an extract of mouse thymus. Levels of activity were also low in aging mice and again could be restored by thymic extract treatment. The most profound fall with aging was in the proliferating pre-T cell compartment as detected by tritiated thymidine suicide; and this compartment was restored by thymic extract treatment. Irradiation to the thymus, with the bone marrow shielded, caused a fall in resting pre-T cells in the bone marrow and a concomitant rise in proliferating cells. These results are consistent with a model of control of pre-T cell maturation in which the thymus senses the number of developing lymphocytes within it and responds to a fall in this number by increasing production of hormone. The hormone acts on resting pre-T cells in the marrow, stimulating some of them to proliferate, leave the bone marrow, and repopulate the thymus. |
| ISSN | 00278424 |
| e-ISSN | 10916490 |
| Journal | Proceedings of the National Academy of Sciences of the United States of America |
| Issue Number | 12 |
| Volume Number | 76 |
| Language | English |
| Publisher | National Academy of Sciences |
| Publisher Date | 1979-01-01 |
| Publisher Place | United States |
| Access Restriction | Open |
| Subject Keyword | Bone Marrow Cells Hematopoiesis T-Lymphocytes Physiology Thymus Hormones Aging Animals Animals, Newborn Immunology Cell Division Radiation Effects Mice Thymectomy Thymus Gland Research Support, U.S. Gov't, P.H.S. Multidisciplinary |
| Content Type | Text |
| Resource Type | Article |
| Subject | Multidisciplinary |
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