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A human thymus-leukemia antigen defined by hybridoma monoclonal antibodies.

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A human thymus-leukemia antigen defined by hybridoma monoclonal antibodies.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Warnke, R. Fox, R. I. Dilley, J. Levy, R.
Abstract	A series of mouse hybridomas producing monoclonal antibodies against human acute lymphocytic leukemia (ALL) cells was generated and screened for tumor specificity. Among 1200 primary cultures, 60 produced an antibody that could distinguish between the immunizing leukemia cells and an isologous B lymphoblastoid cell line. Of these, two produced an antibody that detects an antigen expressed preferentially on ALL cells and on a subpopulation of normal cells found in the cortex of the thymus. Other normal human lymphoid cells from lymph nodes, spleen, bone marrow, and peripheral blood express only low levels of this antigen. High levels of this 'thymus-leukemia' antigen were found on T-ALL cells, T-ALL-derived cell lines, and some 'null' ALL cells. By contrast, B-cell leukemias, B lymphoblastoid cell lines, and normal and malignant myeloid cells contain either low or undetectable amounts of this antigen. The thymus-leukemia antigen has been isolated from the membranes of leukemia cells by detergent solubilization and subsequent immunoprecipitation with the monoclonal antibody. Preliminary biochemical characterization shows the antigen to be associated with a polypeptide of Mr approximately 28,000.
ISSN	00278424
e-ISSN	10916490
Journal	Proceedings of the National Academy of Sciences of the United States of America
Issue Number	12
Volume Number	76
Language	English
Publisher	National Academy of Sciences
Publisher Date	1979-01-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Antigens, Neoplasm Antigens, Surface Leukemia, Lymphoid Immunology T-Lymphocytes Thymus Gland Antibody Specificity Isolation & Purification Clone Cells Hybrid Cells Molecular Weight Spleen Research Support, U.S. Gov't, P.H.S. Multidisciplinary
Content Type	Text
Resource Type	Article
Subject	Multidisciplinary

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