NDLI: Anti-K562 cell monoclonal antibodies recognize hematopoietic progenitors.

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Anti-K562 cell monoclonal antibodies recognize hematopoietic progenitors.

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Anti-K562 cell monoclonal antibodies recognize hematopoietic progenitors.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Young, N. S. Hwang-chen, S. P.
Abstract	The K562 leukemia cell has properties of self-renewal and pluripotency similar to those of the hematopoietic stem cell. Monoclonal antibodies to K562 cells have been produced by using hybridoma technology. By radioimmunoassay, some anti-K562 cell antibodies also bind to erythrocyte antigens or peripheral blood mononuclear cells; others are more specific for K562 cells. Antibody binding to hematopoietic progenitors was assayed by using the ability of these cells to form colonies in vitro. After exposure of human bone marrow cells to anti-K562 antibodies and complement, myeloid or erythroid colony formation was inhibited. Some of the inhibitory antibodies showed little binding to mature blood cells by radioimmunoassay, immunofluorescence, and complement cytotoxicity, suggesting that they recognize antigens specific to undifferentiated cells. With the fluorescence-activated cell sorter, one inhibitory antibody was shown to stain only 3% of bone marrow cells. Inhibitory anti-K562 antibodies also bind to myelogenous leukemia cells and virus-transformed lymphocytes. Thus, these antibodies appear to recognize antigens shared by normal hematopoietic progenitors, leukemic cells, and transformed lymphocytes.
ISSN	00278424
e-ISSN	10916490
Journal	Proceedings of the National Academy of Sciences of the United States of America
Issue Number	11
Volume Number	78
Language	English
Publisher	National Academy of Sciences
Publisher Date	1981-01-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Antibodies, Monoclonal Hematopoietic Stem Cells Immunology Leukemia, Experimental Animals Cell Line Cytotoxicity, Immunologic Fluorescent Antibody Technique Hybridomas Mice Mice, Inbred BALB C Microscopy, Fluorescence Radioimmunoassay Multidisciplinary
Content Type	Text
Resource Type	Article
Subject	Multidisciplinary

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