NDLI: Characterization of an antigenic determinant of the glycoprotein that correlates with pathogenicity of rabies virus.

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Double-stranded RNA-dependent phosphorylation of protein P1 and eukaryotic initiation factor 2 alpha does not correlate with protein synthesis inhibition in a cell-free system from interferon-treated mouse L cells.

Characterization of an antigenic determinant of the glycoprotein that correlates with pathogenicity of rabies virus.

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Characterization of an antigenic determinant of the glycoprotein that correlates with pathogenicity of rabies virus.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Dietzschold, B. Smith, C. L. Lopes, A. D. Wunner, W. H. Wiktor, T. J. Lafon, M. Koprowski, H.
Abstract	The pathogenicity of fixed rabies virus strains for adult mice depends on the presence of an antigenic determinant on the viral glycoprotein. Two virus-neutralizing monoclonal antibodies have been used to identify this determinant. All pathogenic strains of fixed rabies virus bind to these antibodies and are neutralized by them, whereas nonpathogenic strains fail to react with these monoclonal antibodies and are not neutralized by them. Antigenic variants of the rabies virus with altered glycoprotein were selected by growing virus in the presence of one monoclonal antibody, 194-2. All variants that lost their ability to react with this antibody and an additional antibody, 248-8, were found to be nonpathogenic for adult mice. Analysis of tryptic peptides of the glycoproteins of pathogenic parent virus and nonpathogenic variants and the amino acid sequence of a specific variant tryptic peptide revealed that the change in pathogenicity corresponded to an amino acid substitution at position 333 of the glycoprotein molecule. The nucleotide sequence of the nonpathogenic variant glycoprotein gene contained a base change that confirmed the single amino acid substitution in the tryptic peptide replacing arginine-333 in the parental glycoprotein. We conclude that arginine-333 is essential for the integrity of an antigenic determinant and for the ability of rabies viruses to produce lethal infection in adult mice.
ISSN	00278424
e-ISSN	10916490
Journal	Proceedings of the National Academy of Sciences of the United States of America
Issue Number	1
Volume Number	80
Language	English
Publisher	National Academy of Sciences
Publisher Date	1983-03-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Rabies Virus Pathogenicity Viral Proteins Immunology Amino Acid Sequence Antibodies, Monoclonal Epitopes Glycoproteins Research Support, U.S. Gov't, P.H.S. Multidisciplinary
Content Type	Text
Resource Type	Article
Subject	Multidisciplinary

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