NDLI: Hemagglutinin of swine influenza virus: a single amino acid change pleiotropically affects viral antigenicity and replication.

Please wait, while we are loading the content...

Year: 2017 Volume: 114

Year: 2016 Volume: 113

Year: 2015 Volume: 112

Year: 2014 Volume: 111

Year: 2013 Volume: 110

Year: 2012 Volume: 109

Year: 2011 Volume: 108

Year: 2010 Volume: 107

Year: 2009 Volume: 106

Year: 2008 Volume: 105

Year: 2007 Volume: 104

Year: 2006 Volume: 103

Year: 2005 Volume: 102

Year: 2004 Volume: 101

Year: 2003 Volume: 100

Year: 2002 Volume: 99

Year: 2001 Volume: 98

Year: 2000 Volume: 97

Year: 1999 Volume: 96

Year: 1998 Volume: 95

Year: 1997 Volume: 94

Year: 1996 Volume: 93

Year: 1995 Volume: 92

Year: 1994 Volume: 91

Year: 1993 Volume: 90

Year: 1992 Volume: 89

Year: 1991 Volume: 88

Year: 1990 Volume: 87

Year: 1989 Volume: 86

Year: 1988 Volume: 85

Year: 1987 Volume: 84

Year: 1986 Volume: 83

Year: 1985 Volume: 82

Year: 1984 Volume: 81

Year: 1983 Volume: 80

Year: 1983 Volume: 80 Issue: 24

Year: 1983 Volume: 80 Issue: 23

Year: 1983 Volume: 80 Issue: 22

Biosynthesis of renin: multiplicity of active and intermediate forms.

Partial cDNA sequence to a hamster gene corrects defect in Escherichia coli pyrB mutant.

Inhibition of transcription in somatic cells by microinjection of antibodies to chromosomal proteins.

Selective cleavage in the avian retroviral long terminal repeat sequence by the endonuclease associated with the alpha beta form of avian reverse transcriptase.

Engineering of site-directed antisera against vertebrate calmodulin by using synthetic peptide immunogens containing an immunoreactive site.

Alteration and activation of sequence-specific cleavage of DNA by bleomycin in the presence of the antitumor drug cis-diamminedichloroplatinum(II).

Immunological crossreactivity of eukaryotic C1-tetrahydrofolate synthase and prokaryotic 10-formyltetrahydrofolate synthetase.

Polypeptides immunologically related to band 3 are present in nucleated somatic cells.

High-resolution chromosomal localization of human genes for amylase, proopiomelanocortin, somatostatin, and a DNA fragment (D3S1) by in situ hybridization.

Different 3' end points of deletions causing delta beta-thalassemia and hereditary persistence of fetal hemoglobin: implications for the control of gamma-globin gene expression in man.

Stable low molecular weight DNA in xeroderma pigmentosum cells.

Genetic recombination of bacteriophage lambda DNAs in Xenopus oocytes.

Targeted selection of recombinant clones through gene dosage effects.

A specific phosphoprotein phosphatase acts on histone H1 phosphorylated by protein kinase C.

Identification of a transposon Tn3 sequence required for transposition immunity.

A perfectly symmetric lac operator binds the lac repressor very tightly.

Definition of oriR, the minimum DNA segment essential for initiation of R1 plasmid replication in vitro.

Affinity labeling and partial purification of nerve growth factor receptors from rat pheochromocytoma and human melanoma cells.

Structural similarities between the development-specific protein S from a gram-negative bacterium, Myxococcus xanthus, and calmodulin.

Use of gene fusions and protein-protein interaction in the isolation of a biologically active regulatory protein: the replication initiator protein of plasmid R6K.

Nucleotide sequence of the structural gene for diphtheria toxin carried by corynebacteriophage beta.

Monoclonal antibodies that prevent adhesion of B 16 melanoma cells and reduce metastases in mice: crossreaction with human tumor cells.

Calmodulin-binding proteins that interact with actin filaments in a Ca2+-dependent flip-flop manner: survey in brain and secretory tissues.

Molecular mechanisms of human hemoglobin switching: selective undermethylation and expression of globin genes in embryonic, fetal, and adult erythroblasts.

Transformasomes: specialized membranous structures that protect DNA during Haemophilus transformation.

Mitochondrial DNA heteroplasmy in Drosophila mauritiana.

Molecular map of the murine S region.

Restriction fragment length polymorphisms associated with immunoglobulin C gamma genes reveal linkage disequilibrium and genomic organization.

Hybrid gamma 2b-gamma 2a genes expressed in myeloma variants: evidence for homologous recombination.

Monoclonal antibodies against the antigen receptor on a cloned T-cell hybrid.

Glucocorticoids regulate proopiomelanocortin gene expression in vivo at the levels of transcription and secretion.

Human T-cell leukemia virus type II transforms normal human lymphocytes.

Anticodon loop size and sequence requirements for recognition of formylmethionine tRNA by methionyl-tRNA synthetase.

Location of eight ribosomal proteins on the surface of the 50S subunit from Escherichia coli.

ATP-dependent protein kinase-catalyzed phosphorylation of a seryl residue in HPr, a phosphate carrier protein of the phosphotransferase system in Streptococcus pyogenes.

Thermodynamics of assembly of Escherichia coli aspartate transcarbamoylase.

Gene conversion and associated reciprocal recombination are separable events in vegetative cells of Saccharomyces cerevisiae.

Carbon starvation and growth rate-dependent regulation of the Escherichia coli ribosomal RNA promoters: differential control of dual promoters.

Sequence-specific double-strand cleavage of DNA by penta-N-methylpyrrolecarboxamide-EDTA X Fe(II).

Activation of the heme-stabilized translational inhibitor of reticulocyte lysates by calcium ions and phospholipid.

Purified rat brain calcium- and phospholipid-dependent protein kinase phosphorylates ribosomal protein S6.

Autogenous production of a hemopoietic growth factor, persisting-cell-stimulating factor, as a mechanism for transformation of bone marrow-derived cells.

Transcriptional activation of an unrearranged and untranslocated c-myc oncogene by translocation of a C lambda locus in Burkitt.

Characterization of the human receptor for T-cell growth factor.

Electrophoretic analysis of human HLA-DR antigens from HLA-DR4 homozygous cell lines: correlation between beta-chain diversity and HLA-D.

A monoclonal anti-platelet antibody with decreased reactivity for autoimmune thrombocytopenic platelets.

Correlation between rate constant for reduction and redox potential as a basis for systematic investigation of reaction mechanisms of electron transfer proteins.

Latent tissue plasminogen activator produced by human endothelial cells in culture: evidence for an enzyme-inhibitor complex.

Isolation of a genomic clone for bovine pancreatic trypsin inhibitor by using a unique-sequence synthetic DNA probe.

Plasma membrane retrieval in neoplastic pancreatic acinar cells.

Specific DNA sequences associated with the nuclear matrix in synchronized mouse 3T3 cells.

Arylsulfatase in natural killer cells: its possible role in cytotoxicity.

Hemagglutinin of swine influenza virus: a single amino acid change pleiotropically affects viral antigenicity and replication.

Prothrombin is activated on vascular endothelial cells by factor Xa and calcium.

Use of a monoclonal antibody as a substrate for mature neurons in vitro.

Lipid metabolism of isolated oligodendrocytes maintained in long-term culture mimics events associated with myelinogenesis.

Comparative risk analysis of technological hazards (a review).

Oxygenation of hydrocarbons by cytochrome P-450 model compounds: modification of reactivity by axial ligands.

Resonance Raman studies of nitric oxide binding to ferric and ferrous hemoproteins: detection of Fe(III)--NO stretching, Fe(III)--N--O bending, and Fe(II)--N--O bending vibrations.

Structural homology of corticotropin-releasing factor, sauvagine, and urotensin I: circular dichroism and prediction studies.

Year: 1983 Volume: 80 Issue: 21

Year: 1983 Volume: 80 Issue: 20

Year: 1983 Volume: 80 Issue: 19

Year: 1983 Volume: 80 Issue: 18

Year: 1983 Volume: 80 Issue: 17

Year: 1983 Volume: 80 Issue: 16

Year: 1983 Volume: 80 Issue: 15

Year: 1983 Volume: 80 Issue: 14

Year: 1983 Volume: 80 Issue: 13

Year: 1983 Volume: 80 Issue: 12

Year: 1983 Volume: 80 Issue: 11

Year: 1983 Volume: 80 Issue: 10

Year: 1983 Volume: 80 Issue: 9

Year: 1983 Volume: 80 Issue: 8

Year: 1983 Volume: 80 Issue: 7

Year: 1983 Volume: 80 Issue: 6

Year: 1983 Volume: 80 Issue: 5

Year: 1983 Volume: 80 Issue: 4

Year: 1983 Volume: 80 Issue: 3

Year: 1983 Volume: 80 Issue: 2

Year: 1983 Volume: 80 Issue: 1

Year: 1982 Volume: 79

Year: 1981 Volume: 78

Year: 1980 Volume: 77

Year: 1979 Volume: 76

Year: 1978 Volume: 75

Year: 1977 Volume: 74

Year: 1976 Volume: 73

Year: 1975 Volume: 72

Year: 1974 Volume: 71

Year: 1973 Volume: 70

Year: 1972 Volume: 69

Year: 1971 Volume: 68

Year: 1970 Volume: 67

Year: 1970 Volume: 66

Year: 1970 Volume: 65

Year: 1969 Volume: 64

Year: 1969 Volume: 63

Year: 1969 Volume: 62

Year: 1968 Volume: 61

Year: 1968 Volume: 60

Year: 1968 Volume: 59

Year: 1967 Volume: 58

Year: 1967 Volume: 57

Year: 1966 Volume: 56

Year: 1966 Volume: 55

Hemagglutinin of swine influenza virus: a single amino acid change pleiotropically affects viral antigenicity and replication.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Shi, C. H. Kilbourne, E. D. Both, G. W.
Abstract	The complete nucleotide sequence has been obtained of the H1 hemagglutinin (HA) gene of a high-yielding (H) mutant of the A/NJ/11/76(H1N1) strain of swine influenza virus in studies of a viral reassortant (X-53a) bearing this gene. This determination has permitted comparison with human influenza H1N1 prototype viruses A/WSN/33 and A/PR/8/34, with which 80% and 94% amino acid homology was found between HA1 and HA2, respectively. Partial sequences have been determined for other viral reassortants containing either H or L (low-yielding phenotype) genes derived from A/NJ/11/76. Sequence of the HA1 region of an L mutant prototype was virtually completed and differed from that of the H mutant by only four amino acid changes. Sequence analysis of four other viruses was restricted to regions of the HA with which monoclonal antibodies capable of distinguishing L and H mutants are presumed to react. Therefore, changes in these sequences are relevant to changes in viral phenotype. Change at residue 155 from Gly to Glu is associated with change from L to H HA phenotype. This site, structurally equivalent to amino acid 158 on the Wiley et al. HA model [Wiley, D. C., Wilson, I. A. & Skehel, J. J. (1981) Nature (London) 289, 373-378] is near the tip of the HA monomer adjacent to the proposed receptor binding site and therefore credibly could influence both viral antigenicity and replication. Because both L and H variants exist in nature and because revertants may be selected in the laboratory as replication variants in the absence of immunoselection, these studies provide evidence for fortuitous antigenic change in association with change in biological function, which is determined by a single base change.
ISSN	00278424
e-ISSN	10916490
Journal	Proceedings of the National Academy of Sciences of the United States of America
Issue Number	22
Volume Number	80
Language	English
Publisher	National Academy of Sciences
Publisher Date	1983-01-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Genes, Viral Hemagglutinins, Viral Genetics Influenza A Virus Immunology Antigens, Viral DNA Replication Isolation & Purification Phenotype Virus Replication Research Support, U.S. Gov't, P.H.S. Multidisciplinary
Content Type	Text
Resource Type	Article
Subject	Multidisciplinary

Central Library (ISO-9001:2015 Certified)
Indian Institute of Technology Kharagpur
Kharagpur, West Bengal, India | PIN - 721302

See location in the Map
03222 282435
Mail: support@ndl.gov.in

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in