NDLI: Evidence for an intracellular precursor for human B-cell growth factor.

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Evidence for an intracellular precursor for human B-cell growth factor.

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Evidence for an intracellular precursor for human B-cell growth factor.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Maizel, A. Martin, B. Wright, D. Sharma, S. Mehta, S. Sahasrabuddhe, C. G. Morgan, J.
Abstract	Human B-cell growth factor has been described as a trypsin-sensitive protein of Mr 12,000-14,000. Evidence is provided herein that this relatively low molecular weight product may be released from a larger precursor molecule of Mr 60,000-80,000. The precursor protein is confined to the cytosol of freshly isolated T lymphocytes, and only the Mr 12,000-14,000 moiety is released upon lectin stimulation. The precursor protein was subjected to limited tryptic digestion, which demonstrated that the biologically active fraction of the moiety resided in a relatively low molecular weight fragment. The T lymphocyte routinely possessed an intracytoplasmic pool of the precursor protein, the amount of which cyclically varied depending upon its depletion by the secretion process of a lower molecular weight product. Analysis of the mRNA size coding for the majority of B-cell growth factor activity, determined by translation in Xenopus laevis oocytes, suggested that the B-cell growth factor-specific mRNA resided in the greater than or equal to 15S range. This value is consistent with the size of the larger precursor. Therefore, it is proposed that a precursor-product relationship exists for the processing of human B-cell growth factor, analogous to that which has been described for several other cytokines.
ISSN	00278424
e-ISSN	10916490
Journal	Proceedings of the National Academy of Sciences of the United States of America
Issue Number	24
Volume Number	81
Language	English
Publisher	National Academy of Sciences
Publisher Date	1984-01-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	B-Lymphocytes Immunology Growth Substances Genetics Lymphokines Animals Cytosol Metabolism Biosynthesis Interleukin-4 Kinetics Molecular Weight Peptide Fragments Poly A Protein Biosynthesis Protein Precursors RNA RNA, Messenger Trypsin Xenopus Laevis Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S. Multidisciplinary
Content Type	Text
Resource Type	Article
Subject	Multidisciplinary

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