NDLI: Brain and muscle nicotinic acetylcholine receptors are different but homologous proteins.

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Brain and muscle nicotinic acetylcholine receptors are different but homologous proteins.

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Brain and muscle nicotinic acetylcholine receptors are different but homologous proteins.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Raftery, M. A. Lai, F. A. Dunn, S. M. Ray, N. Conti-tronconi, B. M. Barnard, E. A. Dolly, J. O.
Abstract	An alpha-bungarotoxin-binding protein was purified from chick optic lobe and brain by an improved method. Previous and present observations justify its designation as a brain nicotinic acetylcholine receptor (AcChoR). It contains subunits whose apparent molecular weights are somewhat larger than those of subunits of peripheral AcChoRs. The size of the optic lobe AcChoR complex is greater than that of the peripheral receptor when estimated from its sedimentation behavior. Brain AcChoR subunits can be specifically precipitated by a monoclonal antibody directed against chick muscle AcChoR. Amino-terminal amino acid sequence analysis was performed on AcChoR preparations and isolated subunits from the optic lobe and from the rest of the chick brain. The sequences obtained demonstrate that, at least for the lowest molecular weight component, the AcChoRs from different brain areas are identical and they are highly homologous to muscle AcChoR. It is concluded that the brain alpha-bungarotoxin-binding protein is indeed a nicotinic AcChoR and is encoded by a set of genes that is different from, but strongly related to, that for the muscle AcChoR.
ISSN	00278424
e-ISSN	10916490
Journal	Proceedings of the National Academy of Sciences of the United States of America
Issue Number	15
Volume Number	82
Language	English
Publisher	National Academy of Sciences
Publisher Date	1985-09-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Brain Chemistry Muscles Chemistry Receptors, Nicotinic Isolation & Purification Amino Acid Sequence Amino Acids Animals Biological Evolution Bungarotoxins Muscle Proteins Nerve Tissue Proteins Tectum Mesencephali Comparative Study Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, Non-P.H.S. Research Support, U.S. Gov't, P.H.S. Multidisciplinary
Content Type	Text
Resource Type	Article
Subject	Multidisciplinary

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