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The role of ascorbic acid in senile cataract.

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The role of ascorbic acid in senile cataract.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Bensch, K. G. Fleming, J. E. Lohmann, W.
Abstract	The reductone ascorbic acid, present in the crystalline lens in concentrations higher than those of glucose, is capable of undergoing nonenzymatic 'browning' in the presence of lenticular proteins. We studied the nonenzymatic browning with ascorbate in model systems employing bovine serum albumin and lens crystallins. When bovine serum albumin, alpha-crystallin, or gamma-crystallin was incubated with [14C]ascorbic acid, the formation of yellow and then brown condensation products appeared to correlate with increasing protein-associated radioactivity. The fluorescence spectrum of these products was similar to that of homogenates of human cataractous lenses. We suggest that the nonenzymatic reaction of lens crystallins with ascorbic acid may contribute, at least in part, to the color changes of aging lenses and to the physical lenticular deterioration leading to senile cataract. High dietary intake of ascorbic acid did not affect the fluorescence spectrum of murine lenses; thus, we assume that the speed and extent of the lenticular browning reactions must depend on a deterioration of other factors of the multicomponent antioxidant system of the eye.
ISSN	00278424
e-ISSN	10916490
Journal	Proceedings of the National Academy of Sciences of the United States of America
Issue Number	21
Volume Number	82
Language	English
Publisher	National Academy of Sciences
Publisher Date	1985-12-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Ascorbic Acid Metabolism Cataract Crystallins Anaerobiosis Animals Antioxidants Toxicity Carbohydrate Metabolism Chemically Induced Fluorescence Free Radicals Glutathione Reductase Physiology Mice Oxidation-Reduction Serum Albumin, Bovine Research Support, Non-U.S. Gov't Multidisciplinary
Content Type	Text
Resource Type	Article
Subject	Multidisciplinary

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