NDLI: Multiple genes encode nuclear factor 1-like proteins that bind to the promoter for 3-hydroxy-3-methylglutaryl-coenzyme A reductase.

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Multiple genes encode nuclear factor 1-like proteins that bind to the promoter for 3-hydroxy-3-methylglutaryl-coenzyme A reductase.

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Multiple genes encode nuclear factor 1-like proteins that bind to the promoter for 3-hydroxy-3-methylglutaryl-coenzyme A reductase.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Slaughter, C. A. Goldstein, J. L. Gil, G. Smith, J. R. Brown, M. S. Orth, K. Osborne, T. F.
Description	Author Affiliation: Gil G ( Department of Molecular Genetics, University of Texas Southwestern Medical Center, Dallas 75235.);
Abstract	DNA-binding proteins of the nuclear factor 1 (NF1) family recognize sequences containing TGG. Two of these proteins, termed reductase promoter factor (RPF) proteins A and B, bind to the promoter for hamster 3-hydroxy-3-methylglutaryl-coenzyme A reductase, a negatively regulated enzyme in cholesterol biosynthesis. In the current study, we determined the sequences of peptides derived from hamster RPF proteins A and B and used this information to isolate a cDNA, designated pNF1/Red1, that encodes RPF protein B. The peptide sequence of RPF protein A, the other reductase-related protein, suggests that it is the hamster equivalent of NF1/L, which was previously cloned from rat liver. We also isolated a hamster cDNA for an additional member of the NF1 family, designated NF1/X. Thus, the hamster genome contains at least three genes for NF1-like proteins. It is likely to contain a fourth gene, corresponding to NF1/CTF, which was previously cloned from the human. The NH2-terminal sequences of all four NF1-like proteins (NF1/Red1, NF1/L, NF1/X, and NF1/CTF), which are virtually identical, contain the DNA-binding domain that recognizes TGG. Functional diversity may arise from differences in the COOH-terminal sequences. We hypothesize that the COOH-terminal domain interacts with adjacent DNA-binding proteins, thereby stabilizing the binding of a particular NF1-like protein to a particular promoter. This protein-protein interaction confers specificity to a class of proteins whose DNA-recognition sequence is widespread in the genome. Sterols may repress transcription of the reductase gene by disrupting this protein-protein interaction.
ISSN	00278424
e-ISSN	10916490
Journal	Proceedings of the National Academy of Sciences of the United States of America
Issue Number	23
Volume Number	85
Language	English
Publisher	National Academy of Sciences
Publisher Date	1988-12-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	CCAAT-Enhancer-Binding Proteins DNA-Binding Proteins Genetics Genes Hydroxymethylglutaryl CoA Reductases Promoter Regions, Genetic Transcription Factors Amino Acid Sequence Animals Cloning, Molecular Cricetinae Gene Expression Regulation Liver Metabolism Mesocricetus Molecular Sequence Data NFI Transcription Factors Nuclear Proteins Transcription, Genetic Y-Box-Binding Protein 1 Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S. Multidisciplinary
Content Type	Text
Resource Type	Article
Subject	Multidisciplinary

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