NDLI: Patch-clamp study of gamma-aminobutyric acid receptor Cl- channels in cultured astrocytes.

Please wait, while we are loading the content...

Year: 2017 Volume: 114

Year: 2016 Volume: 113

Year: 2015 Volume: 112

Year: 2014 Volume: 111

Year: 2013 Volume: 110

Year: 2012 Volume: 109

Year: 2011 Volume: 108

Year: 2010 Volume: 107

Year: 2009 Volume: 106

Year: 2008 Volume: 105

Year: 2007 Volume: 104

Year: 2006 Volume: 103

Year: 2005 Volume: 102

Year: 2004 Volume: 101

Year: 2003 Volume: 100

Year: 2002 Volume: 99

Year: 2001 Volume: 98

Year: 2000 Volume: 97

Year: 1999 Volume: 96

Year: 1998 Volume: 95

Year: 1997 Volume: 94

Year: 1996 Volume: 93

Year: 1995 Volume: 92

Year: 1994 Volume: 91

Year: 1993 Volume: 90

Year: 1992 Volume: 89

Year: 1991 Volume: 88

Year: 1990 Volume: 87

Year: 1989 Volume: 86

Year: 1988 Volume: 85

Year: 1988 Volume: 85 Issue: 24

Year: 1988 Volume: 85 Issue: 23

Beta gamma subunits of GTP-binding proteins inhibit muscarinic receptor stimulation of phospholipase C.

Adenosine regulates the Ca2+ sensitivity of mast cell mediator release.

Characterization of the minor groove environment in a drug-DNA complex: bisbenzimide bound to the poly[d(AT)].poly[d(AT)]duplex.

Rapid production of full-length cDNAs from rare transcripts: amplification using a single gene-specific oligonucleotide primer.

cAMP-mediated phosphorylation of the low-Km cAMP phosphodiesterase markedly stimulates its catalytic activity.

An analysis of T-cell receptor variable region gene expression in major histocompatibility complex disparate mice.

Coexpression of granulocyte-macrophage colony-stimulating factor, gamma interferon, and interleukins 3 and 4 is random in murine alloreactive T-lymphocyte clones.

Effect of mutations and variations of HLA-A2 on recognition of a virus peptide epitope by cytotoxic T lymphocytes.

Binding region for human immunodeficiency virus (HIV) and epitopes for HIV-blocking monoclonal antibodies of the CD4 molecule defined by site-directed mutagenesis.

Fetal hemoglobin synthesis in vivo: direct evidence for control at the level of erythroid progenitors.

Reversion toward an earlier stage of differentiation and loss of polarity during progression of N-methyl-N-nitrosourea-induced rat mammary tumours.

Patch-clamp study of gamma-aminobutyric acid receptor Cl- channels in cultured astrocytes.

Long-term sensitization in Aplysia increases the number of presynaptic contacts onto the identified gill motor neuron L7.

Vasopressin modulates the spontaneous electrical activity in aortic cells (line A7r5) by acting on three different types of ionic channels.

Human papillomavirus type 16 cooperates with activated ras and fos oncogenes in the hormone-dependent transformation of primary mouse cells.

NF-kappa B protein purification from bovine spleen: nucleotide stimulation and binding site specificity.

Identification of phosphorylated 422(aP2) protein as pp15, the 15-kilodalton target of the insulin receptor tyrosine kinase in 3T3-L1 adipocytes.

DNA gyrase binds to the family of prokaryotic repetitive extragenic palindromic sequences.

Human DNA topoisomerase I is encoded by a single-copy gene that maps to chromosome region 20q12-13.2.

Phosphorylation of nitrogen regulator I (NRI) of Escherichia coli.

Identification and purification of a Drosophila protein that binds to the terminal 31-base-pair inverted repeats of the P transposable element.

Isolation of a full-length cDNA insert encoding human aromatase system cytochrome P-450 and its expression in nonsteroidogenic cells.

SecA suppresses the temperature-sensitive SecY24 defect in protein translocation in Escherichia coli membrane vesicles.

Purified secB protein of Escherichia coli retards folding and promotes membrane translocation of the maltose-binding protein in vitro.

Characterization of a cDNA clone encoding the calmodulin-binding domain of mouse brain calcineurin.

Polyomavirus early-late switch is not regulated at the level of transcription initiation and is associated with changes in RNA processing.

Efficient transactivation and morphologic transformation by bovine papillomavirus genes expressed from a bovine papillomavirus/simian virus 40 recombinant virus.

Beta-cell lines derived from transgenic mice expressing a hybrid insulin gene-oncogene.

Antibody to phosphatidylinositol 4,5-bisphosphate inhibits oncogene-induced mitogenesis.

Synthesis of an opine-like compound, a rhizopine, in alfalfa nodules is symbiotically regulated.

Intrachromosomal rearrangements mediated by hobo transposons in Drosophila melanogaster.

Localization of human ERBA2 to the 3p22----3p24.1 region of chromosome 3 and variable deletion in small cell lung cancer.

Even transcriptionally competent proviruses are silent in bovine leukemia virus-induced sheep tumor cells.

Stress-induced alterations of immunity in hypophysectomized rats.

Aberrant expression of receptors for platelet-derived growth factor in an anaplastic thyroid carcinoma cell line.

Epstein-Barr virus (EBV) infection of murine L cells expressing recombinant human EBV/C3d receptor.

Guanosine 5'-monophosphate modulates gating of high-conductance Ca2+-activated K+ channels in vascular smooth muscle cells.

Cloning and nucleotide sequence of human gamma-glutamyl transpeptidase.

Probing the Escherichia coli glnALG upstream activation mechanism in vivo.

Inhibition of H+-transporting ATPase by formation of a tight nucleoside diphosphate-fluoroaluminate complex at the catalytic site.

Evidence that a point mutation in dihydrofolate reductase-thymidylate synthase confers resistance to pyrimethamine in falciparum malaria.

Long-term potentiation differentially affects two components of synaptic responses in hippocampus.

Antiserum raised against residues 159-168 of the guanine nucleotide-binding protein Gi3-alpha reacts with ependymal cells and some neurons in the rat brain containing cholecystokinin- or cholecystokinin- and tyrosine 3-hydroxylase-like immunoreactivities.

Additional low-abundance human small nuclear ribonucleoproteins: U11, U12, etc.

Fluorescence in situ hybridization with human chromosome-specific libraries: detection of trisomy 21 and translocations of chromosome 4.

Release of IgD-binding factor by T cells under the influence of interleukin 2, interleukin 4, or cross-linked IgD.

Expression of CD3-associated antigen-binding receptors on suppressor T cells.

Signal transduction from membrane to cytoplasm: growth factors and membrane-bound oncogene products increase Raf-1 phosphorylation and associated protein kinase activity.

A nuclease that cuts specifically in the ribosome binding site of some T4 mRNAs.

A mutant human proinsulin is secreted from islets of Langerhans in increased amounts via an unregulated pathway.

Promoters largely determine the efficiency of repressor action.

Structure of the reaction center from Rhodobacter sphaeroides R-26 and 2.4.1: symmetry relations and sequence comparisons between different species.

Amino acid changes linked to pyrimethamine resistance in the dihydrofolate reductase-thymidylate synthase gene of Plasmodium falciparum.

Overproduction of the epsilon subunit of DNA polymerase III counteracts the SOS mutagenic response of Escherichia coli.

A sensitive molecular assay for mutagenesis in mammalian cells: reversion analysis in cells with a mutant shuttle vector gene integrated into chromosomal DNA.

Escherichia coli mutY gene product is required for specific A-G----C.G mismatch correction.

Synthesis and expression in Escherichia coli of the gene encoding monocyte-derived neutrophil-activating factor: biological equivalence between natural and recombinant neutrophil-activating factor.

Human granulocyte-macrophage colony-stimulating factor is a growth factor active on a variety of cell types of nonhemopoietic origin.

Analysis of RAS oncogene mutations in human lymphoid malignancies.

Characterization of invasion plasmid antigen genes (ipaBCD) from Shigella flexneri.

Measurement of local cerebral protein synthesis in vivo: influence of recycling of amino acids derived from protein degradation.

Heteroatom-substituted fatty acid analogs as substrates for N-myristoyltransferase: an approach for studying both the enzymology and function of protein acylation.

Evidence for a trans-acting factor that regulates the transcription of class II major histocompatibility complex genes: genetic and functional analysis.

His-426 of the Pseudomonas aeruginosa exotoxin A is required for ADP-ribosylation of elongation factor II.

Dual mechanism of repression at a distance in the lac operon.

Deletion of transfected oncogenes from NIH 3T3 transformants by inhibitors of poly(ADP-ribose) polymerase.

Recombinant tumor necrosis factor increases pulmonary vascular permeability independent of neutrophils.

Detection of benzo[a]pyrene diol epoxide-DNA adducts in human placenta.

Transformation of an interleukin 3-dependent hematopoietic cell line by the chronic myelogenous leukemia-specific P210bcr/abl protein.

Milk lipid globules: control of their size distribution.

Energy metabolism of the untrained muscle of elite runners as observed by 31P magnetic resonance spectroscopy: evidence suggesting a genetic endowment for endurance exercise.

Determination of DNA structures by NMR and distance geometry techniques: a computer simulation.

Detection of nucleic acid hybridization by nonradiative fluorescence resonance energy transfer.

DNA damage-inducible transcripts in mammalian cells.

Metal-specific synthesis of two metallothioneins and gamma-glutamyl peptides in Candida glabrata.

Complete amino acid sequence of human placental protein 14: a progesterone-regulated uterine protein homologous to beta-lactoglobulins.

A human 200-kDa protein binds selectively to DNA fragments containing G.T mismatches.

Reexamination of the kinetics of the transfer of NADH between its complexes with glycerol-3-phosphate dehydrogenase and with lactate dehydrogenase.

Pituitary-specific expression and glucocorticoid regulation of a proopiomelanocortin fusion gene in transgenic mice.

Down-regulation of c-myb gene expression is a prerequisite for erythropoietin-induced erythroid differentiation.

Different structures in the amino-terminal domain of the ornithine transcarbamylase leader peptide are involved in mitochondrial import and carboxyl-terminal cleavage.

cDNA encoding the glycosyl-phosphatidylinositol-specific phospholipase C of Trypanosoma brucei.

Cocrystal structure of an editing complex of Klenow fragment with DNA.

Multiple genes encode nuclear factor 1-like proteins that bind to the promoter for 3-hydroxy-3-methylglutaryl-coenzyme A reductase.

Structure and nucleotide sequence of the rat intestinal vitamin D-dependent calcium binding protein gene.

Relationship between transient DNA hypomethylation and erythroid differentiation of murine erythroleukemia cells.

Ca2+ transient, Mg2+, and pH measurements in the cardiac cycle by 19F NMR.

Evidence for expression of the facilitated glucose transporter in rat hepatocytes.

Decreased de novo synthesis of proteoglycans in drug-induced renal cystic disease.

Selective and indirect modulation of human multipotential and erythroid hematopoietic progenitor cell proliferation by recombinant human activin and inhibin.

Multiple protein 4.1 isoforms produced by alternative splicing in human erythroid cells.

Conditional enhancement of liver-specific gene transcription.

Isolation and sequence determination of a cDNA clone for rat peroxisomal urate oxidase: liver-specific expression in the rat.

Defining cellular senescence in IMR-90 cells: a flow cytometric analysis.

Glucocorticoids both stimulate and inhibit production of pulmonary surfactant protein A in fetal human lung.

Tandemly repeated tRNA pseudogenes in photobacterium.

Admixture as a tool for finding linked genes and detecting that difference from allelic association between loci.

Structure and chromosomal localization of the functional intronless human JUN protooncogene.

Chromosomal translocation in T-cell leukemia line HUT 78 results in a MYC fusion transcript.

High frequency of mosaic mutants produced by N-ethyl-N-nitrosourea exposure of mouse zygotes.

Analysis of a T-cell tumor-specific breakpoint cluster at human chromosome 14q32.

M13 repeat probe detects DNA minisatellite-like sequences in gymnosperms and angiosperms.

Anti-immunoglobulin pretreatment induces a calcium-mobilization response to the chemotactic agent N-formylmethionylleucylphenylalanine in Daudi lymphoblastoid cells.

Missense mutations in an infectious human immunodeficiency viral genome: functional mapping of tat and identification of the rev splice acceptor.

Effects of passive immunization in patients with the acquired immunodeficiency syndrome-related complex and acquired immunodeficiency syndrome.

Purification and characterization of a bovine acetyl low density lipoprotein receptor.

Processing of the structural proteins of human immunodeficiency virus type 1 in the presence of monensin and cerulenin.

Juxtaposition of the T-cell receptor alpha-chain locus (14q11) and a region (14q32) of potential importance in leukemogenesis by a 14;14 translocation in a patient with T-cell chronic lymphocytic leukemia and ataxia-telangiectasia.

Mammalian cerebral cortical tissue responds to low-intensity visible light.

Suppression and induction of epileptic activity by neuronal grafts.

Localization of glucocorticoid receptor mRNA in the male rat brain by in situ hybridization.

Classification of the European language families by genetic distance.

Erythropoietin changes the globin program of an interleukin 3-dependent multipotential cell line.

Formation of IgE-binding factors by T cells of patients infected with human immunodeficiency virus type 1.

Aminosugar derivatives as potential anti-human immunodeficiency virus agents.

Role of protein N-glycosylation in pathogenesis of human immunodeficiency virus type 1.

Year: 1988 Volume: 85 Issue: 22

Year: 1988 Volume: 85 Issue: 21

Year: 1988 Volume: 85 Issue: 20

Year: 1988 Volume: 85 Issue: 19

Year: 1988 Volume: 85 Issue: 18

Year: 1988 Volume: 85 Issue: 17

Year: 1988 Volume: 85 Issue: 16

Year: 1988 Volume: 85 Issue: 15

Year: 1988 Volume: 85 Issue: 14

Year: 1988 Volume: 85 Issue: 13

Year: 1988 Volume: 85 Issue: 12

Year: 1988 Volume: 85 Issue: 11

Year: 1988 Volume: 85 Issue: 10

Year: 1988 Volume: 85 Issue: 9

Year: 1988 Volume: 85 Issue: 8

Year: 1988 Volume: 85 Issue: 7

Year: 1988 Volume: 85 Issue: 6

Year: 1988 Volume: 85 Issue: 5

Year: 1988 Volume: 85 Issue: 4

Year: 1988 Volume: 85 Issue: 3

Year: 1988 Volume: 85 Issue: 2

Year: 1988 Volume: 85 Issue: 1

Year: 1987 Volume: 84

Year: 1986 Volume: 83

Year: 1985 Volume: 82

Year: 1984 Volume: 81

Year: 1983 Volume: 80

Year: 1982 Volume: 79

Year: 1981 Volume: 78

Year: 1980 Volume: 77

Year: 1979 Volume: 76

Year: 1978 Volume: 75

Year: 1977 Volume: 74

Year: 1976 Volume: 73

Year: 1975 Volume: 72

Year: 1974 Volume: 71

Year: 1973 Volume: 70

Year: 1972 Volume: 69

Year: 1971 Volume: 68

Year: 1970 Volume: 67

Year: 1970 Volume: 66

Year: 1970 Volume: 65

Year: 1969 Volume: 64

Year: 1969 Volume: 63

Year: 1969 Volume: 62

Year: 1968 Volume: 61

Year: 1968 Volume: 60

Year: 1968 Volume: 59

Year: 1967 Volume: 58

Year: 1967 Volume: 57

Year: 1966 Volume: 56

Year: 1966 Volume: 55

Patch-clamp study of gamma-aminobutyric acid receptor Cl- channels in cultured astrocytes.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Kettenmann, H. Bormann, J.
Description	Author Affiliation: Bormann J ( Max-Planck-Institut für biophysikalische Chemie, Göttingen, Federal Republic of Germany.);
Abstract	The membrane channels operated by gamma-aminobutyric acid (GABA) were studied in cultured astrocytes from rat cerebral hemispheres by using patch-clamp techniques. The channel properties appeared to be very similar, in many respects, to those present in neuronal cell membranes. The Cl- -selective channels were activated after the sequential binding of two GABA molecules to the receptor, as deduced from the slope of the dose-response curve. Single-channel currents displayed multiple conductance states of 12 pS, 21 pS, 29 pS, and 43 pS, with the main-state conductance being 29 pS. The gating properties could be described by a sequential reaction scheme for agonist-activated channels. GABA-induced whole-cell currents were potentiated by the benzodiazepine receptor agonist diazepam and also, to a lesser extent, by methyl 6,7-dimethoxy-4-ethyl-beta-carboline-3-carboxylate an inverse agonist. In neurons and chromaffin cells, methyl 6,7-dimethoxy-4-ethyl-beta-carboline-3-carboxylate reduces the sensitivity of the GABA receptor, indicating that neuronal and glial GABA/benzodiazepine receptor--Cl- channel complexes are different. Glial GABA receptor channels could be of functional importance in buffering extracellular Cl- in the cleft of the GABAergic synapse.
ISSN	00278424
e-ISSN	10916490
Journal	Proceedings of the National Academy of Sciences of the United States of America
Issue Number	23
Volume Number	85
Language	English
Publisher	National Academy of Sciences
Publisher Date	1988-12-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Astrocytes Cytology Chlorides Metabolism Ion Channels Physiology Receptors, GABA-A Animals Animals, Newborn Brain Cells, Cultured Electric Conductivity Membrane Potentials Drug Effects Rats, Inbred Strains Gamma-Aminobutyric Acid Pharmacology Research Support, Non-U.S. Gov't Multidisciplinary
Content Type	Text
Resource Type	Article
Subject	Multidisciplinary

Central Library (ISO-9001:2015 Certified)
Indian Institute of Technology Kharagpur
Kharagpur, West Bengal, India | PIN - 721302

See location in the Map
03222 282435
Mail: support@ndl.gov.in

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in