NDLI: Vaccinia DNA topoisomerase I promotes illegitimate recombination in Escherichia coli.

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Vaccinia DNA topoisomerase I promotes illegitimate recombination in Escherichia coli.

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Vaccinia DNA topoisomerase I promotes illegitimate recombination in Escherichia coli.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Shuman, S.
Description	Author Affiliation: Shuman S ( Program in Molecular Biology, Sloan-Kettering Institute, New York, NY 10021.);
Abstract	Vaccinia virus encapsidates a Mr 32,000 type IDNA topoisomerase. Although the vaccinia gene encoding the topoisomerase is essential for virus growth, the role of the enzyme in vivo remains unclear. In the present study, the physiologic consequences of vaccinia topoisomerase action have been examined in a heterologous system, Escherichia coli. The vaccinia topoisomerase gene was inducibly expressed in an int-lambda lysogen BL21(DE3) using a T7 RNA polymerase-based transcription system. Expression of active topoisomerase in this context resulted in recA-dependent lysogenic induction as well as cell lysis. Surprisingly, topoisomerase expression also effected a 200-fold increase in the titer of infectious lambda phage, apparently by promoting int-independent prophage excision. This effect was not observed during lysogenic induction with nalidixic acid. Restriction analysis of genomic DNA from plaque-purified excisants revealed (in 10 of 10 cases) gross alterations of the DNA structure around the att site relative to the structure of the parental phage DE3. It is construed therefore that vaccinia DNA topoisomerase I acts to promote illegitimate recombination in E. coli.
ISSN	00278424
e-ISSN	10916490
Journal	Proceedings of the National Academy of Sciences of the United States of America
Issue Number	10
Volume Number	86
Language	English
Publisher	National Academy of Sciences
Publisher Date	1989-06-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	DNA Topoisomerases, Type I Physiology Escherichia Coli Genetics Recombination, Genetic Vaccinia Virus Enzymology Cloning, Molecular Multidisciplinary
Content Type	Text
Resource Type	Article
Subject	Multidisciplinary

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