NDLI: Single-channel recording in myelinated nerve fibers reveals one type of Na channel but different K channels.

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Single-channel recording in myelinated nerve fibers reveals one type of Na channel but different K channels.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Hermsteiner, M. Vogel, W. Jonas, P. Bräu, M. E.
Description	Author Affiliation: Jonas P ( Physiologisches Institut der Justus-Liebig-Universität, Giessen, Federal Republic of Germany.);
Abstract	Amphibian myelinated nerve fibers were treated with collagenase and protease. Axons with retraction of the myelin sheath were patch-clamped in the nodal and paranodal region. One type of Na channel was found. It has a single-channel conductance of 11 pS (15 degrees C) and is blocked by tetrodotoxin. Averaged events show the typical activation and inactivation kinetics of macroscopic Na current. Three potential-dependent K channels were identified (I, F, and S channel). The I channel, being the most frequent type, has a single-channel conductance of 23 pS (inward current, 105 mM K on both sides of the membrane), activates between -60 and -30 mV, deactivates with intermediate kinetics, and is sensitive to dendrotoxin. The F channel has a conductance of 30 pS, activates between -40 and 60 mV, and deactivates with fast kinetics. The former inactivates within tens of seconds; the latter inactivates within seconds. The third type, the S channel, has a conductance of 7 pS and deactivates slowly. All three channels can be blocked by external tetraethylammonium chloride. We suggest that these distinct K channel types form the basis for the different components of macroscopic K current described previously.
ISSN	00278424
e-ISSN	10916490
Journal	Proceedings of the National Academy of Sciences of the United States of America
Issue Number	18
Volume Number	86
Language	English
Publisher	National Academy of Sciences
Publisher Date	1989-10-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Nerve Fibers, Myelinated Physiology Potassium Channels Sciatic Nerve Sodium Channels Animals Axons Ultrastructure Kinetics Membrane Potentials Xenopus Laevis Research Support, Non-U.S. Gov't Multidisciplinary
Content Type	Text
Resource Type	Article
Subject	Multidisciplinary

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