NDLI: DNA variation of the mammalian major histocompatibility complex reflects genomic diversity and population history.

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DNA variation of the mammalian major histocompatibility complex reflects genomic diversity and population history.

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DNA variation of the mammalian major histocompatibility complex reflects genomic diversity and population history.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Yuhki, N. O'brien, S. J.
Description	Author Affiliation: Yuhki N ( Laboratory of Viral Carcinogenesis, National Cancer Institute, Frederick, MD 21701-1013.);
Abstract	The major histocompatibility complex (MHC) is a multigene complex of tightly linked homologous genes that encode cell surface antigens that play a key role in immune regulation and response to foreign antigens. In most species, MHC gene products display extreme antigenic polymorphism, and their variability has been interpreted to reflect an adaptive strategy for accommodating rapidly evolving infectious agents that periodically afflict natural populations. Determination of the extent of MHC variation has been limited to populations in which skin grafting is feasible or for which serological reagents have been developed. We present here a quantitative analysis of restriction fragment length polymorphism of MHC class I genes in several mammalian species (cats, rodents, humans) known to have very different levels of genetic diversity based on functional MHC assays and on allozyme surveys. When homologous class I probes were employed, a notable concordance was observed between the extent of MHC restriction fragment variation and functional MHC variation detected by skin grafts or genome-wide diversity estimated by allozyme screens. These results confirm the genetically depauperate character of the African cheetah, Acinonyx jubatus, and the Asiatic lion, Panthera leo persica; further, they support the use of class I MHC molecular reagents in estimating the extent and character of genetic diversity in natural populations.
ISSN	00278424
e-ISSN	10916490
Journal	Proceedings of the National Academy of Sciences of the United States of America
Issue Number	2
Volume Number	87
Language	English
Publisher	National Academy of Sciences
Publisher Date	1990-03-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	DNA Genetics Genetic Variation Major Histocompatibility Complex Animals Carnivora Cricetinae Isolation & Purification Genes, MHC Class I Lions Mathematics Mesocricetus Mice Mice, Inbred Strains Models, Genetic Organ Specificity Polymorphism, Restriction Fragment Length Species Specificity Comparative Study Multidisciplinary
Content Type	Text
Resource Type	Article
Subject	Multidisciplinary

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