NDLI: Nonhomologous chromatid exchange in hereditary and sporadic renal cell carcinomas.

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Nonhomologous chromatid exchange in hereditary and sporadic renal cell carcinomas.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Kung, H. F. Kovacs, G.
Description	Author Affiliation: Kovacs G ( Biological Carcinogenesis and Development Program, Program Resources, Incorporated, Frederick, MD.);
Abstract	For the development of renal cell carcinomas, it has been suggested that a germ-line or somatic mutation occurs on one of the homologous chromosomes 3p, and subsequently the other 3p segment is lost. We have examined the karyotype and/or the allelic combination on chromosomes 3 and 5 by restriction fragment length polymorphism analysis in normal kidney and tumor samples from 28 renal cell carcinomas that developed in two patients with von Hippel-Lindau disease; we then compared the results to those of sporadic tumors. An unbalanced translocation between chromosome 3p and 5q or other chromosomes was found to be the most common aberration. We developed a model of nonhomologous chromatid exchange involving breakpoint clusters at chromosomes 3p13, 3p11.2, 5q22, and 8q11.2. Subsequent chromatid segregation may result in net loss of the 3p segment either (i) in one step or (ii) after a nondisjunctional loss of the derivative chromosome carrying the 3p segment. This general mechanism could also be implicated to explain genetic changes occurring in other types of solid tumors.
ISSN	00278424
e-ISSN	10916490
Journal	Proceedings of the National Academy of Sciences of the United States of America
Issue Number	1
Volume Number	88
Language	English
Publisher	National Academy of Sciences
Publisher Date	1991-02-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Carcinoma, Renal Cell Genetics Crossing Over, Genetic Kidney Neoplasms Translocation, Genetic Blotting, Southern Chromatids Physiology Chromosome Banding DNA, Neoplasm Isolation & Purification Genotype In Vitro Techniques Karyotyping Nucleic Acid Hybridization Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S. Multidisciplinary
Content Type	Text
Resource Type	Article
Subject	Multidisciplinary

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