NDLI: Responses of single germinal-center B cells in T-cell-dependent microculture.

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Responses of single germinal-center B cells in T-cell-dependent microculture.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	George, A. Cebra, J. J.
Description	Author Affiliation: George A ( Department of Biology, University of Pennsylvania, Philadelphia 19104-6018.);
Abstract	B cells purified from the germinal centers (GCs) of murine Peyer's patches can be stimulated in a clonal microculture containing helper T cells and dendritic cells to divide and secrete immunoglobulin. Intraclonal isotype switching occurs, and a variety of immunoglobulin isotypes, including IgA, is secreted. Memory cells, which generate clones secreting IgA exclusively, are only rarely identified in the GC B-cell subset. Such memory cells can, however, be readily identified among unfractionated Peyer's patch B cells, and in non-GC subsets of B cells. The results suggest that the GC does not contain IgA memory cells that can be restimulated in vitro to secrete only IgA. When division of GC B cells is prevented by irradiation or aphidicholin treatment, a large subset that secretes IgA as the sole immunoglobulin isotype is seen, and the output of presumably single B cells is large enough to be scored by RIA. Both helper T cells and dendritic cells are required for the phenomenon. The data indicate that commitment to IgA secretion occurs in Peyer's patch GCs and suggest that the prolific cell division known to be supported in GCs may forestall terminal differentiation of preplasmablasts to immunoglobulin secretion.
ISSN	00278424
e-ISSN	10916490
Journal	Proceedings of the National Academy of Sciences of the United States of America
Issue Number	1
Volume Number	88
Language	English
Publisher	National Academy of Sciences
Publisher Date	1991-02-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	B-Lymphocytes Immunology Dendritic Cells T-Lymphocytes, Helper-Inducer Animals Antibody Formation Aphidicolin Cytology Drug Effects Clone Cells Crosses, Genetic DNA Replication Diterpenes Pharmacology Flow Cytometry Haplotypes Immunoglobulin A Immunosuppressive Agents Mice Mice, Inbred BALB C Mice, Inbred C3H Mice, Inbred C57BL Peyer's Patches Research Support, U.S. Gov't, P.H.S. Multidisciplinary
Content Type	Text
Resource Type	Article
Subject	Multidisciplinary

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