NDLI: Dhr6, a Drosophila homolog of the yeast DNA-repair gene RAD6.

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Dhr6, a Drosophila homolog of the yeast DNA-repair gene RAD6.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Koken, M. Bootsma, D. Reynolds, P. Hoeijmakers, J. Prakash, S. Prakash, L.
Description	Author Affiliation: Koken M ( Department of Cell Biology and Genetics, Erasmus University, Rotterdam, The Netherlands.);
Abstract	The RAD6 gene of the yeast Saccharomyces cerevisiae is required for DNA repair, for DNA damage-induced mutagenesis, and for sporulation, and it encodes a ubiquitin-conjugating enzyme. We have cloned the RAD6 homolog from Drosophila melanogaster and find that its encoded protein displays a very high degree of identity in amino acid sequence with the homologous RAD6 proteins from the two divergent yeasts, S. cerevisiae and Schizosaccharomyces pombe, and from human. Genetic complementation studies indicate that the Drosophila RAD6 homolog can functionally substitute for the S. cerevisiae RAD6 gene in its DNA-repair and UV-mutagenesis functions but cannot substitute in sporulation. The high degree of structural and functional conservation of RAD6 in eukaryotic evolution suggests that the various protein components involved in RAD6-dependent DNA repair and mutagenesis functions have also been conserved.
ISSN	00278424
e-ISSN	10916490
Journal	Proceedings of the National Academy of Sciences of the United States of America
Issue Number	9
Volume Number	88
Language	English
Publisher	National Academy of Sciences
Publisher Date	1991-05-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	DNA Repair Drosophila Proteins Drosophila Melanogaster Genetics Genes Ligases Saccharomyces Cerevisiae Ubiquitin-Conjugating Enzymes Amino Acid Sequence Animals Blotting, Northern Blotting, Southern Cloning, Molecular Gene Expression Genetic Complementation Test In Vitro Techniques Molecular Sequence Data RNA, Messenger Schizosaccharomyces Comparative Study Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S. Multidisciplinary
Content Type	Text
Resource Type	Article
Subject	Multidisciplinary

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