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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Rhee, S. G. Park, D. J. Rho, H. W. |
| Description | Author Affiliation: Park DJ ( Section on Signal Transduction, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892.); |
| Abstract | The human T-cell line Jurkat was found to contain at least two immunologically distinct isoforms of inositol phospholipid-specific phospholipase C (PLC), PLC-beta 1 and PLC-gamma 1. Treatment of Jurkat cells with antibody to CD3 led to phosphorylation of PLC-gamma 1 but not of PLC-beta 1. The phosphorylation of PLC-gamma 1 occurred rapidly and transiently on both serine and tyrosine residues; tyrosine phosphorylation reached a maximum level less than 1 min after stimulation and decreased rapidly, both in the presence and in the absence of orthovanadate. Two-dimensional phosphopeptide map analysis revealed that the major sites of tyrosine and serine phosphorylation in PLC-gamma 1 from activated Jurkat cells are the same as those in PLC-gamma 1 from cells treated with peptide growth factors such as epidermal growth factor and platelet-derived growth factor. Previously, it has been shown that multiple phosphorylation of PLC-gamma 1 by the growth factor receptor tyrosine kinases leads to activation of PLC-gamma 1. Thus, the current data suggest that inositol phospholipid hydrolysis triggered by the T-cell antigen receptor-CD3 complex is due, at least in part, to activation of PLC-gamma 1 and that the mechanism by which this activation is achieved involves phosphorylation of multiple tyrosine residues on PLC-gamma 1 by a nonreceptor tyrosine kinase coupled to the T-cell antigen receptor-CD3 complex. |
| ISSN | 00278424 |
| e-ISSN | 10916490 |
| Journal | Proceedings of the National Academy of Sciences of the United States of America |
| Issue Number | 12 |
| Volume Number | 88 |
| Language | English |
| Publisher | National Academy of Sciences |
| Publisher Date | 1991-07-01 |
| Publisher Place | United States |
| Access Restriction | Open |
| Subject Keyword | Antigens, Differentiation, T-Lymphocyte Immunology Isoenzymes Metabolism Receptors, Antigen, T-Cell Serine T-Lymphocytes Type C Phospholipases Tyrosine Antibodies, Monoclonal Antigens, CD3 Blotting, Western Cell Line Peptide Mapping Phosphorylation Precipitin Tests Trypsin Research Support, Non-U.S. Gov't Multidisciplinary |
| Content Type | Text |
| Resource Type | Article |
| Subject | Multidisciplinary |
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