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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Zouzias, D. C. Zucker-franklin, D. Rush, M. G. Coutavas, E. E. |
| Description | Author Affiliation: Zucker-Franklin D ( Department of Medicine, New York University Medical Center, NY 10016.); |
| Abstract | Because of seronegativity and absence of a leukemic phase in most patients with mycosis fungoides, a role for the human T-lymphotropic virus type I (HTLV-I) in this disease has remained tenuous. Virus particles are not seen in fresh isolates of skin or blood lymphocytes and the malignant cells (Sézary cells) have been difficult to culture. The availability of growth factors and biomolecular techniques have prompted a renewed attempt to find evidence of virus infection in these patients. We report here the successful culture of blood lymphocytes of 17 patients with mycosis fungoides and 1 patient with the Sézary syndrome. The cells of 2 additional patients failed to grow after 4-6 weeks in vitro. Ultrastructural analysis of the cultures showed an abundance of HTLV-like particles in the specimens of 18 of the 20 patients. Preliminary immunohistochemical studies carried out with various antisera directed against HTLV-I and the polymerase chain reaction utilizing a probe for a conserved region of the pol gene of HTLV-I were positive on only a portion of the specimens. Although definitive characterization of this organism awaits further analysis, it seems likely that circulating lymphocytes of all patients with mycosis fungoides harbor a virus that morphologically resembles HTLV-I. |
| ISSN | 00278424 |
| e-ISSN | 10916490 |
| Journal | Proceedings of the National Academy of Sciences of the United States of America |
| Issue Number | 17 |
| Volume Number | 88 |
| Language | English |
| Publisher | National Academy of Sciences |
| Publisher Date | 1991-10-01 |
| Publisher Place | United States |
| Access Restriction | Open |
| Subject Keyword | DNA, Viral Isolation & Purification Human T-lymphotropic Virus 1 Lymphocytes Microbiology Monocytes Mycosis Fungoides Blotting, Southern Cells, Cultured Genetics Fluorescent Antibody Technique Ultrastructure Microscopy, Electron Blood Polymerase Chain Reaction Research Support, U.S. Gov't, P.H.S. Multidisciplinary |
| Content Type | Text |
| Resource Type | Article |
| Subject | Multidisciplinary |
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