NDLI: Discrimination between related DNA sites by a single amino acid residue of Myc-related basic-helix-loop-helix proteins.

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Discrimination between related DNA sites by a single amino acid residue of Myc-related basic-helix-loop-helix proteins.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Dolde, C. Gillison, M. L. Kato, G. J. Dang, C. V.
Description	Author Affiliation: Dang CV ( Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205.);
Abstract	A yeast genetic system was developed to study how the basic regions of basic-helix-loop-helix (bHLH) proteins distinguish between related consensus bHLH binding sites, with nucleotide sequence CANNTG. The yeast bHLH protein CBF1 binds to the sequence CAC(A/G)TG found in the yeast centromere element CDE1 and in promoter regions of several yeast genes involved in methionine biosynthesis. Using a functional assay to rescue a mutant cbf1 yeast strain from methionine auxotrophy, we determined that the basic region of CBF1 could be replaced by the homologous region of either the vertebrate USF transcription factor or c-Myc, both of which bind CACGTG. The homologous region of the AP4 transcription factor, which recognizes the sequence CAGCTG, could not functionally replace the CBF1 basic region. However, only a single substitution, Met----Arg, in the AP4 basic region of the inactive chimera CBF-AP4 was sufficient to restore CBF1 function. In randomization experiments, only arginine or lysine provided functional substitutions at the AP4 methionine position. The results suggest that this conserved arginine residue in the basic regions of Myc-related bHLH proteins discriminates between CAC(A/G)TG and related sites.
ISSN	00278424
e-ISSN	10916490
Journal	Proceedings of the National Academy of Sciences of the United States of America
Issue Number	2
Volume Number	89
Language	English
Publisher	National Academy of Sciences
Publisher Date	1992-02-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	DNA-Binding Proteins Chemistry Transcription Factors Amino Acid Sequence Arginine Binding Sites DNA Mutational Analysis Molecular Sequence Data Proto-Oncogene Proteins C-myc Metabolism Saccharomyces Cerevisiae Structure-Activity Relationship Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S. Multidisciplinary
Content Type	Text
Resource Type	Article
Subject	Multidisciplinary

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