NDLI: Efficient inhibition of P-glycoprotein-mediated multidrug resistance with a monoclonal antibody.

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Inhibition of assimilatory nitrate reductase activity in soil by glutamine and ammonium analogs.

Intracellular amplification and expression of a synthetic analog of rotavirus genomic RNA bearing a foreign marker gene: mapping cis-acting nucleotides in the 3'-noncoding region.

Cloned human neuropeptide Y receptor couples to two different second messenger systems.

Viral E1 and E2 proteins support replication of homologous and heterologous papillomaviral origins.

Functional binding of the 'TATA' box binding component of transcription factor TFIID to the -30 region of TATA-less promoters.

Human chromosomal localization of genes encoding the gamma 1 and gamma 2 subunits of the gamma-aminobutyric acid receptor indicates that members of this gene family are often clustered in the genome.

Recognition of the Epstein-Barr virus-encoded nuclear antigens EBNA-4 and EBNA-6 by HLA-A11-restricted cytotoxic T lymphocytes: implications for down-regulation of HLA-A11 in Burkitt lymphoma.

Membrane-bound Dictyostelium myosin heavy chain kinase: a developmentally regulated substrate-specific member of the protein kinase C family.

Hormonal regulation of the thyrotropin beta-subunit gene by phosphorylation of the pituitary-specific transcription factor Pit-1.

Transient immunoglobulin M antibody response to hepatitis C virus capsid antigen in posttransfusion hepatitis C: putative serological marker for acute viral infection.

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A dominant mutation in the Wilms tumor gene WT1 cooperates with the viral oncogene E1A in transformation of primary kidney cells.

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Vitamin D-responsive protein-DNA interactions at multiple promoter regulatory elements that contribute to the level of rat osteocalcin gene expression.

Parental bias of Ki-ras oncogenes detected in lung tumors from mouse hybrids.

Efficient inhibition of P-glycoprotein-mediated multidrug resistance with a monoclonal antibody.

Recombinant anti-erbB2 immunotoxins containing Pseudomonas exotoxin.

Design and synthesis of a CD4 beta-turn mimetic that inhibits human immunodeficiency virus envelope glycoprotein gp120 binding and infection of human lymphocytes.

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On the nature of global classification.

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Efficient inhibition of P-glycoprotein-mediated multidrug resistance with a monoclonal antibody.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Roninson, I. B. Mechetner, E. B.
Description	Author Affiliation: Mechetner EB ( Department of Genetics, University of Illinois, Chicago, IL 60612.);
Abstract	P-glycoprotein (Pgp), encoded by the MDR1 gene, is an active efflux pump for many structurally diverse lipophilic compounds. Cellular expression of Pgp results in multidrug resistance (MDR) in vitro and is believed to be a clinically relevant mechanism for tumor resistance to chemotherapy. We have developed a mouse monoclonal antibody, UIC2, that recognizes an extracellular epitope of human Pgp. UIC2 inhibited the efflux of Pgp substrates from MDR cells and significantly increased the cytotoxicity of Pgp-transported drugs, under the conditions where no effect was detectable with other anti-Pgp antibodies. Potentiation of cytotoxicity by UIC2 was observed with all the tested drugs associated with MDR (vinblastine, vincristine, colchicine, taxol, doxorubicin, etoposide, actinomycin D, puromycin, and gramicidin D) but not with any of the drugs to which MDR cells are not cross-resistant (methotrexate, 5-fluorouracil, cis-platinum, G418, and gentamicin). The inhibitory effect of UIC2 in vitro was as strong as that of verapamil (a widely used Pgp inhibitor) at its highest clinically achievable concentrations. Our results suggest that UIC2 or its derivatives provide an alternative or supplement to chemical agents for the reversal of MDR in clinical cancer.
ISSN	00278424
e-ISSN	10916490
Journal	Proceedings of the National Academy of Sciences of the United States of America
Issue Number	13
Volume Number	89
Language	English
Publisher	National Academy of Sciences
Publisher Date	1992-08-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Antibodies, Monoclonal Immunology Drug Resistance Membrane Glycoproteins 3T3 Cells Animals Antigen-Antibody Reactions Antigens, Surface Biological Transport Cell Division Drug Effects Mice Mice, Inbred BALB C P-Glycoprotein Vinblastine Toxicity Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S. Multidisciplinary
Content Type	Text
Resource Type	Article
Subject	Multidisciplinary

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