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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Kieff, E. Longnecker, R. Lee, J. H. Miller, C. L. |
| Description | Author Affiliation: Miller CL ( Department of Medicine, Harvard Medical School, Boston, MA 02115.); |
| Abstract | The role of latent membrane protein 2 (LMP2) in Epstein-Barr virus (EBV) infection was evaluated by using latently infected primary B lymphocytes that had been growth transformed by wild-type or specifically mutated EBV recombinants. LMP2 null mutant recombinant EBV-infected cells were similar to normal B lymphocytes in their rapid increase in intracellular free calcium after surface immunoglobulin crosslinking. These cells also became more permissive for lytic EBV replication. In sharp contrast, wild-type control infected cells had little or no increase in intracellular free calcium or in permissivity for EBV replication. The block to surface immunoglobulin crosslinking-induced permissivity in cells expressing wild-type LMP2 could be bypassed by raising intracellular free calcium levels with an ionophore and by activating protein kinase C with phorbol 12-myristate 13-acetate. LMP2A, not LMP2B, mediates this effect on calcium mobilization. Genetic and biochemical data are consistent with these effects being due to the interaction of the LMP2A N-terminal cytoplasmic domain with B lymphocyte src family tyrosine kinases. |
| ISSN | 00278424 |
| e-ISSN | 10916490 |
| Journal | Proceedings of the National Academy of Sciences of the United States of America |
| Issue Number | 2 |
| Volume Number | 91 |
| Language | English |
| Publisher | National Academy of Sciences |
| Publisher Date | 1994-02-01 |
| Publisher Place | United States |
| Access Restriction | Open |
| Subject Keyword | Antigens, Viral Immunology Herpesvirus 4, Human Receptors, Antigen, B-Cell Metabolism Viral Matrix Proteins Amino Acid Sequence Genetics Calcimycin Pharmacology Calcium Capsid Cell Line, Transformed Cell Transformation, Viral Cross-Linking Reagents Physiology Molecular Sequence Data Protein Kinase C Tetradecanoylphorbol Acetate Virus Activation Virus Replication Drug Effects Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S. Multidisciplinary |
| Content Type | Text |
| Resource Type | Article |
| Subject | Multidisciplinary |
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