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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Deluca, H. F. Darwish, H. M. Zierold, C. |
| Description | Author Affiliation: Zierold C ( Department of Biochemistry, College of Agricultural and Life Sciences, University of Wisconsin-Madison 53706.); |
| Abstract | The calcidiol (25-hydroxyvitamin D3) 24-hydroxylase is one of the key enzymes in the metabolism of vitamin D. This enzyme acts on both calcidiol and calcitriol (1,25-dihydroxyvitamin D3) to initiate degradation of these potent vitamin D metabolites and is tightly regulated. Calcitriol itself induces this enzyme and acts at the transcriptional level. Transcriptional regulation of genes by calcitriol has been shown to occur via the vitamin D-receptor binding to a vitamin D-response element located upstream of the transcription start site. We now report a vitamin D-response element located between nt -262 and nt -238 of the rat calcidiol 24-hydroxylase gene. This sequence binds the calcitriol receptor and confers vitamin D-dependent transactivation of transcription to its own, as well as heterologous, promoter. |
| ISSN | 00278424 |
| e-ISSN | 10916490 |
| Journal | Proceedings of the National Academy of Sciences of the United States of America |
| Issue Number | 3 |
| Volume Number | 91 |
| Language | English |
| Publisher | National Academy of Sciences |
| Publisher Date | 1994-03-01 |
| Publisher Place | United States |
| Access Restriction | Open |
| Subject Keyword | Cytochrome P-450 Enzyme System Genetics Steroid Hydroxylases Vitamin D Pharmacology Animals Calcitriol Chloramphenicol O-Acetyltransferase Cloning, Molecular DNA Gene Expression Regulation, Enzymologic Drug Effects Genes, Reporter Molecular Sequence Data Promoter Regions, Genetic Transcription, Genetic Vitamin D3 24-Hydroxylase Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S. Multidisciplinary |
| Content Type | Text |
| Resource Type | Article |
| Subject | Multidisciplinary |
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