NDLI: Binding of beta gamma subunits of heterotrimeric G proteins to the PH domain of Bruton tyrosine kinase.

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Binding of beta gamma subunits of heterotrimeric G proteins to the PH domain of Bruton tyrosine kinase.

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Binding of beta gamma subunits of heterotrimeric G proteins to the PH domain of Bruton tyrosine kinase.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Tsukada, S. Simon, M. I. Witte, O. N. Katz, A.
Description	Author Affiliation: Tsukada S ( Department of Microbiology and Molecular Genetics, University of California, Los Angeles 90024-1662.);
Abstract	Bruton tyrosine kinase (Btk) has been implicated as the defective gene in both human and murine B-cell deficiencies. The identification of molecules that interact with Btk may shed light on critical processes in lymphocyte development. The N-terminal unique region of Btk contains a pleckstrin homology domain. This domain is found in a broad array of signaling molecules and implicated to function in protein-protein interactions. By using an in vitro binding assay and an in vivo competition assay, the pleckstrin homology domain of Btk was shown to interact with the beta gamma dimer of heterotrimeric guanine nucleotide-binding proteins (G proteins). A highly conserved tryptophan residue in subdomain 6 of the pleckstrin homology domain was shown to play a critical role in the binding. The interaction of Btk with beta gamma suggests the existence of a unique connection between cytoplasmic tyrosine kinases and G proteins in cellular signal transduction.
ISSN	00278424
e-ISSN	10916490
Journal	Proceedings of the National Academy of Sciences of the United States of America
Issue Number	23
Volume Number	91
Language	English
Publisher	National Academy of Sciences
Publisher Date	1994-12-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	GTP-Binding Proteins Metabolism Phosphoproteins Protein-Tyrosine Kinases Amino Acid Sequence Animals Blood Proteins Chemistry Cyclic AMP-Dependent Protein Kinases Macromolecular Substances Mice Molecular Sequence Data Protein Binding Sequence Alignment Sequence Homology, Amino Acid Signal Transduction Structure-Activity Relationship Tryptophan Beta-Adrenergic Receptor Kinases Comparative Study Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S. Multidisciplinary
Content Type	Text
Resource Type	Article
Subject	Multidisciplinary

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