NDLI: An alternatively spliced form of the nerve growth factor receptor TrkA confers an enhanced response to neurotrophin 3.

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An alternatively spliced form of the nerve growth factor receptor TrkA confers an enhanced response to neurotrophin 3.

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An alternatively spliced form of the nerve growth factor receptor TrkA confers an enhanced response to neurotrophin 3.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Clary, D. O. Reichardt, L. F.
Description	Author Affiliation: Clary DO ( Department of Physiology, University of California, San Francisco 94143.);
Abstract	TrkA, a member of the receptor tyrosine kinase family, binds nerve growth factor (NGF) and subsequently activates intracellular signaling pathways. Previous studies have found variable and weak interaction of the TrkA receptor with neurotrophin 3 (NT-3), another member of the NGF family. TrkA is expressed in two splice forms, differing in the presence of an 18-bp exon in the extracellular domain. The biological responses of each isoform of the TrkA receptor were tested after transfection into the cell line PC12nnr5, a variant of PC12 cells lacking functional TrkA protein. NGF was found to activate each form of the receptor comparably. However, the TrkA isoform containing the variable exon showed significantly higher activation by NT-3, which was detected by stimulation of TrkA autophosphorylation, induction of ZIF268 transcription, and cellular differentiation. Function-perturbing antibodies to the p75 low-affinity NGF receptor potentiated the NT-3 responses of both forms of TrkA in the transfected PC12nnr5 cell lines, suggesting that the low-affinity NGF receptor suppresses the ability of TrkA to respond to NT-3.
ISSN	00278424
e-ISSN	10916490
Journal	Proceedings of the National Academy of Sciences of the United States of America
Issue Number	23
Volume Number	91
Language	English
Publisher	National Academy of Sciences
Publisher Date	1994-12-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Nerve Growth Factors Pharmacology Proto-Oncogene Proteins Chemistry Receptor Protein-Tyrosine Kinases Receptors, Nerve Growth Factor Alternative Splicing Animals Cell Differentiation Drug Effects Gene Expression Neurotrophin 3 PC12 Cells RNA, Messenger Genetics Receptor, TrkA Signal Transduction Structure-Activity Relationship Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S. Multidisciplinary
Content Type	Text
Resource Type	Article
Subject	Multidisciplinary

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