NDLI: Evidence that neuronal G-protein-gated inwardly rectifying K+ channels are activated by G beta gamma subunits and function as heteromultimers.

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Evidence that neuronal G-protein-gated inwardly rectifying K+ channels are activated by G beta gamma subunits and function as heteromultimers.

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Evidence that neuronal G-protein-gated inwardly rectifying K+ channels are activated by G beta gamma subunits and function as heteromultimers.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Davidson, N. Lester, H. A. Kofuji, P.
Description	Author Affiliation: Kofuji P ( Division of Biology, California Institute of Technology, Pasadena 91225, USA.);
Abstract	Guanine nucleotide-binding proteins (G proteins) activate K+ conductances in cardiac atrial cells to slow heart rate and in neurons to decrease excitability. cDNAs encoding three isoforms of a G-protein-coupled, inwardly rectifying K+ channel (GIRK) have recently been cloned from cardiac (GIRK1/Kir 3.1) and brain cDNA libraries (GIRK2/Kir 3.2 and GIRK3/Kir 3.3). Here we report that GIRK2 but not GIRK3 can be activated by G protein subunits G beta 1 and G gamma 2 in Xenopus oocytes. Furthermore, when either GIRK3 or GIRK2 was coexpressed with GIRK1 and activated either by muscarinic receptors or by G beta gamma subunits, G-protein-mediated inward currents were increased by 5- to 40-fold. The single-channel conductance for GIRK1 plus GIRK2 coexpression was intermediate between those for GIRK1 alone and for GIRK2 alone, and voltage-jump kinetics for the coexpressed channels displayed new kinetic properties. On the other hand, coexpression of GIRK3 with GIRK2 suppressed the GIRK2 alone response. These studies suggest that formation of heteromultimers involving the several GIRKs is an important mechanism for generating diversity in expression level and function of neurotransmitter-coupled, inward rectifier K+ channels.
ISSN	00278424
e-ISSN	10916490
Journal	Proceedings of the National Academy of Sciences of the United States of America
Issue Number	14
Volume Number	92
Language	English
Publisher	National Academy of Sciences
Publisher Date	1995-08-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Brain Physiology GTP-Binding Proteins Neurons Potassium Channels, Inwardly Rectifying Potassium Channels Acetylcholine Pharmacology Animals Metabolism Cloning, Molecular Evoked Potentials G Protein-Coupled Inwardly-Rectifying Potassium Channels Heart Macromolecular Substances Membrane Potentials Drug Effects Mice Myocardium Oocytes Patch-Clamp Techniques Potassium Biosynthesis RNA, Complementary Receptors, Muscarinic Xenopus Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S. Multidisciplinary
Content Type	Text
Resource Type	Article
Subject	Multidisciplinary

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