NDLI: Modulation of c-Myb-induced transcription activation by a phosphorylation site near the negative regulatory domain.

Please wait, while we are loading the content...

Year: 2017 Volume: 114

Year: 2016 Volume: 113

Year: 2015 Volume: 112

Year: 2014 Volume: 111

Year: 2013 Volume: 110

Year: 2012 Volume: 109

Year: 2011 Volume: 108

Year: 2010 Volume: 107

Year: 2009 Volume: 106

Year: 2008 Volume: 105

Year: 2007 Volume: 104

Year: 2006 Volume: 103

Year: 2005 Volume: 102

Year: 2004 Volume: 101

Year: 2003 Volume: 100

Year: 2002 Volume: 99

Year: 2001 Volume: 98

Year: 2000 Volume: 97

Year: 1999 Volume: 96

Year: 1998 Volume: 95

Year: 1997 Volume: 94

Year: 1996 Volume: 93

Year: 1995 Volume: 92

Year: 1995 Volume: 92 Issue: 26

Year: 1995 Volume: 92 Issue: 25

Year: 1995 Volume: 92 Issue: 24

Year: 1995 Volume: 92 Issue: 23

Year: 1995 Volume: 92 Issue: 22

Year: 1995 Volume: 92 Issue: 21

Year: 1995 Volume: 92 Issue: 20

Year: 1995 Volume: 92 Issue: 19

Year: 1995 Volume: 92 Issue: 18

Year: 1995 Volume: 92 Issue: 17

Year: 1995 Volume: 92 Issue: 16

Year: 1995 Volume: 92 Issue: 15

Year: 1995 Volume: 92 Issue: 14

NDR1, a locus of Arabidopsis thaliana that is required for disease resistance to both a bacterial and a fungal pathogen.

Arabidopsis signal transduction mutant defective in chemically and biologically induced disease resistance.

Differentiation between homoeologous chromosomes 1A of wheat and 1Am of Triticum monococcum and its recognition by the wheat Ph1 locus.

Cotranslational folding and calnexin binding during glycoprotein synthesis.

Use of an oocyte expression assay to reconstitute inductive signaling.

Interaction with the recombination hot spot chi in vivo converts the RecBCD enzyme of Escherichia coli into a chi-independent recombinase by inactivation of the RecD subunit.

Presynaptic modulation of cortical synaptic activity by calcineurin.

Overexpression of csk inhibits acid-induced activation of NHE-3.

The choice of alternative 5' splice sites in influenza virus M1 mRNA is regulated by the viral polymerase complex.

Recognition by viral and cellular DNA polymerases of nucleosides bearing bases with nonstandard hydrogen bonding patterns.

Activation of mitogen-activated protein kinases by vascular endothelial growth factor and basic fibroblast growth factor in capillary endothelial cells is inhibited by the antiangiogenic factor 16-kDa N-terminal fragment of prolactin.

Scorpion toxins as natural scaffolds for protein engineering.

Liquid-phase combinatorial synthesis.

Isolation of small polarized bile duct units.

Direct tests of the role of membrane lipid composition in low-temperature-induced photoinhibition and chilling sensitivity in plants and cyanobacteria.

Unsaturation of the membrane lipids of chloroplasts stabilizes the photosynthetic machinery against low-temperature photoinhibition in transgenic tobacco plants.

The DnaJ chaperone catalytically activates the DnaK chaperone to preferentially bind the sigma 32 heat shock transcriptional regulator.

A transgene coding for a human insulin analog has a mitogenic effect on murine embryonic beta cells.

The recombination hot spot chi activates RecBCD recombination by converting Escherichia coli to a recD mutant phenocopy.

Synergy between T-cell immunity and inhibition of paracrine stimulation causes tumor rejection.

The pre-S domain of the large viral envelope protein determines host range in avian hepatitis B viruses.

Mice lacking extracellular superoxide dismutase are more sensitive to hyperoxia.

Enzyme-catalyzed synthesis of poly[(R)-(-)-3-hydroxybutyrate]: formation of macroscopic granules in vitro.

Distribution of the Ixodes ricinus-like ticks of eastern North America.

Growth suppression by p16ink4 requires functional retinoblastoma protein.

Staphylococcal enterotoxins bind H-2Db molecules on macrophages.

SCT1 mutants suppress the camptothecin sensitivity of yeast cells expressing wild-type DNA topoisomerase I.

Immunoglobulin variable region hypermutation in hybrids derived from a pre-B- and a myeloma cell line.

Characterization of a voltage-gated K+ channel beta subunit expressed in human heart.

Location of light-repressible, small GTP-binding protein of the YPT/rab family in the growing zone of etiolated pea stems.

Cyclophilin catalyzes protein folding in yeast mitochondria.

Three-dimensional structure of a cysteine-rich repeat from the low-density lipoprotein receptor.

A single residue in DNA polymerases of the Escherichia coli DNA polymerase I family is critical for distinguishing between deoxy- and dideoxyribonucleotides.

Identification of endothelin 1 and big endothelin 1 in secretory vesicles isolated from bovine aortic endothelial cells.

Periodicity of polar and nonpolar amino acids is the major determinant of secondary structure in self-assembling oligomeric peptides.

Correction of chromosomal instability and sensitivity to diverse mutagens by a cloned cDNA of the XRCC3 DNA repair gene.

Identification of auxin-responsive elements of parB and their expression in apices of shoot and root.

An activity gel assay detects a single, catalytically active histone acetyltransferase subunit in Tetrahymena macronuclei.

Complete congruence between gene diversity estimates derived from genotypic data at enzyme and random amplified polymorphic DNA loci in black spruce.

Real-time detection of DNA hybridization and melting on oligonucleotide arrays by using optical wave guides.

The human plakoglobin gene localizes on chromosome 17q21 and is subjected to loss of heterozygosity in breast and ovarian cancers.

Evolution of single and double Wolbachia symbioses during speciation in the Drosophila simulans complex.

Pleiotropy in microdeletion syndromes: neurologic and spermatogenic abnormalities in mice homozygous for the p6H deletion are likely due to dysfunction of a single gene.

Genetic and redox determinants of nitric oxide cytotoxicity in a Salmonella typhimurium model.

Cloning and sequencing of CATR1.3, a human gene associated with tumorigenic conversion.

Alterations in Notch signaling in neoplastic lesions of the human cervix.

Autoinducer-mediated regulation of rhamnolipid biosurfactant synthesis in Pseudomonas aeruginosa.

Modulation of c-Myb-induced transcription activation by a phosphorylation site near the negative regulatory domain.

Mice develop normally without the H1(0) linker histone.

Directed selection of recombinant human monoclonal antibodies to herpes simplex virus glycoproteins from phage display libraries.

Oligomerization of CD4 is required for stable binding to class II major histocompatibility complex proteins but not for interaction with human immunodeficiency virus gp120.

Calcium-dependent glutamate release during neuronal development and synaptogenesis: different involvement of omega-agatoxin IVA- and omega-conotoxin GVIA-sensitive channels.

Transcriptional activation of human adult alpha-globin genes by hypersensitive site-40 enhancer: function of nuclear factor-binding motifs occupied in erythroid cells.

Characterization of the VHL tumor suppressor gene product: localization, complex formation, and the effect of natural inactivating mutations.

An A-DNA triplet code: thermodynamic rules for predicting A- and B-DNA.

Illusory contours activate specific regions in human visual cortex: evidence from functional magnetic resonance imaging.

A type 1 serine/threonine kinase receptor that can dorsalize mesoderm in Xenopus.

Genetic footprinting: a genomic strategy for determining a gene's function given its sequence.

Inhibition of selective signaling events in natural killer cells recognizing major histocompatibility complex class I.

Construction of a 2.8-megabase yeast artificial chromosome contig and cloning of the human methylthioadenosine phosphorylase gene from the tumor suppressor region on 9p21.

Dietary lipids and calorie restriction affect mammary tumor incidence and gene expression in mouse mammary tumor virus/v-Ha-ras transgenic mice.

The GroES homolog of Helicobacter pylori confers protective immunity against mucosal infection in mice.

Increase of skeletal muscle relaxation speed by direct injection of parvalbumin cDNA.

Incorporation of glutamine repeats makes protein oligomerize: implications for neurodegenerative diseases.

Relatedness threshold for the production of female sexuals in colonies of a polygynous ant, Myrmica tahoensis, as revealed by microsatellite DNA analysis.

Direct evidence for secondary loss of mitochondria in Entamoeba histolytica.

A modified tetracycline-regulated system provides autoregulatory, inducible gene expression in cultured cells and transgenic mice.

Mammalian karyopherin alpha 1 beta and alpha 2 beta heterodimers: alpha 1 or alpha 2 subunit binds nuclear localization signal and beta subunit interacts with peptide repeat-containing nucleoporins.

Anti-melanoma antibodies from melanoma patients immunized with genetically modified autologous tumor cells: selection of specific antibodies from single-chain Fv fusion phage libraries.

Evidence that neuronal G-protein-gated inwardly rectifying K+ channels are activated by G beta gamma subunits and function as heteromultimers.

T lymphocytes that infiltrate tumors and atherosclerotic plaques produce heparin-binding epidermal growth factor-like growth factor and basic fibroblast growth factor: a potential pathologic role.

Alternate protein frameworks for molecular recognition.

Functional domain analysis of glass, a zinc-finger-containing transcription factor in Drosophila.

Different cellular backgrounds confer a marked advantage to either mutant or wild-type mitochondrial genomes.

Naturally processed peptides from two disease-resistance-associated HLA-DR13 alleles show related sequence motifs and the effects of the dimorphism at position 86 of the HLA-DR beta chain.

Shigella flexneri surface protein IcsA is sufficient to direct actin-based motility.

Persistence of immunoglobulin heavy chain/c-myc recombination-positive lymphocyte clones in the blood of human immunodeficiency virus-infected homosexual men.

A kinase associated with chromatin that can be activated by ligand-p185c-Neu or epidermal growth factor-receptor interactions.

A genetic screen identifies cellular factors involved in retroviral -1 frameshifting.

Capturing genes encoding membrane and secreted proteins important for mouse development.

Identification of human brain regions underlying responses to resistive inspiratory loading with functional magnetic resonance imaging.

A chimeric light-regulated amino acid transport system allows the isolation of blue light regulator (blr) mutants of Neurospora crassa.

Ergosteroids: induction of thermogenic enzymes in liver of rats treated with steroids derived from dehydroepiandrosterone.

Mapping a gene causing cerebral cavernous malformation to 7q11.2-q21.

Disparate responses to oxidative stress in saprophytic and pathogenic mycobacteria.

Identification of a gene involved in the biosynthesis of cyclopropanated mycolic acids in Mycobacterium tuberculosis.

cAMP-dependent, long-lasting inhibition of a K+ current in mammalian neurons.

The GA5 locus of Arabidopsis thaliana encodes a multifunctional gibberellin 20-oxidase: molecular cloning and functional expression.

Molecular cloning of bullfrog saxiphilin: a unique relative of the transferrin family that binds saxitoxin. (Journal: Proceedings of the National Academy of Sciences of the United States of America Volume: 92 Issue: 14)

Year: 1995 Volume: 92 Issue: 13

Year: 1995 Volume: 92 Issue: 12

Year: 1995 Volume: 92 Issue: 11

Year: 1995 Volume: 92 Issue: 10

Year: 1995 Volume: 92 Issue: 9

Year: 1995 Volume: 92 Issue: 8

Year: 1995 Volume: 92 Issue: 7

Year: 1995 Volume: 92 Issue: 6

Year: 1995 Volume: 92 Issue: 5

Year: 1995 Volume: 92 Issue: 4

Year: 1995 Volume: 92 Issue: 3

Year: 1995 Volume: 92 Issue: 2

Year: 1995 Volume: 92 Issue: 1

Year: 1994 Volume: 91

Year: 1993 Volume: 90

Year: 1992 Volume: 89

Year: 1991 Volume: 88

Year: 1990 Volume: 87

Year: 1989 Volume: 86

Year: 1988 Volume: 85

Year: 1987 Volume: 84

Year: 1986 Volume: 83

Year: 1985 Volume: 82

Year: 1984 Volume: 81

Year: 1983 Volume: 80

Year: 1982 Volume: 79

Year: 1981 Volume: 78

Year: 1980 Volume: 77

Year: 1979 Volume: 76

Year: 1978 Volume: 75

Year: 1977 Volume: 74

Year: 1976 Volume: 73

Year: 1975 Volume: 72

Year: 1974 Volume: 71

Year: 1973 Volume: 70

Year: 1972 Volume: 69

Year: 1971 Volume: 68

Year: 1970 Volume: 67

Year: 1970 Volume: 66

Year: 1970 Volume: 65

Year: 1969 Volume: 64

Year: 1969 Volume: 63

Year: 1969 Volume: 62

Year: 1968 Volume: 61

Year: 1968 Volume: 60

Year: 1968 Volume: 59

Year: 1967 Volume: 58

Year: 1967 Volume: 57

Year: 1966 Volume: 56

Year: 1966 Volume: 55

Modulation of c-Myb-induced transcription activation by a phosphorylation site near the negative regulatory domain.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Hendrickson, R. C. Bender, T. P. Shabanowitz, J. Aziz, N. Miglarese, M. R. Hunt, D. F. Sturgill, T. W.
Description	Author Affiliation: Aziz N ( Department of Pharmacology, University of Virginia, Charlottesville 22908, USA.);
Abstract	The c-myb protooncogene encodes a highly conserved transcription factor that functions as both an activator and a repressor of transcription. The v-myb oncogenes of E26 leukemia virus and avian myeloblastosis virus encode proteins that are truncated at both the amino and the carboxyl terminus, deleting portions of the c-Myb DNA-binding and negative regulatory domains. This has led to speculation that the deleted regions contain important regulatory sequences. We previously reported that the 42-kDa mitogen-activated protein kinase (p42mapk) phosphorylates chicken and murine c-Myb at multiple sites in the negative regulatory domain in vitro, suggesting that phosphorylation might provide a mechanism to regulate c-Myb function. We now report that three tryptic phosphopeptides derived from in vitro phosphorylated c-Myb comigrate with three tryptic phosphopeptides derived from metabolically labeled c-Myb immunoprecipitated from murine erythroleukemia cells. At least two of these peptides are phosphorylated on serine-528. Replacement of serine-528 with alanine results in a 2- to 7-fold increase in the ability of c-Myb to transactivate a Myb-responsive promoter/reporter gene construct. These findings suggest that phosphorylation serves to regulate c-Myb activity and that loss of this phosphorylation site from the v-Myb proteins may contribute to their transforming potential.
ISSN	00278424
e-ISSN	10916490
Journal	Proceedings of the National Academy of Sciences of the United States of America
Issue Number	14
Volume Number	92
Language	English
Publisher	National Academy of Sciences
Publisher Date	1995-08-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Oncogenes Proto-Oncogene Proteins Metabolism Transcription, Genetic Amino Acid Sequence Animals Avian Myeloblastosis Virus Genetics Cell Line Cercopithecus Aethiops DNA-Binding Proteins Gene Expression Regulation, Neoplastic Glutathione Transferase Biosynthesis Isolation & Purification Kidney Leukemia Virus, Murine Leukemia, Erythroblastic, Acute Mice Molecular Sequence Data Peptide Mapping Phosphopeptides Chemistry Phosphoproteins Protein-Tyrosine Kinases Proto-Oncogene Proteins C-myb Recombinant Fusion Proteins Regulatory Sequences, Nucleic Acid Serine Transcriptional Activation Transfection Tumor Cells, Cultured Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S. Multidisciplinary
Content Type	Text
Resource Type	Article
Subject	Multidisciplinary

Central Library (ISO-9001:2015 Certified)
Indian Institute of Technology Kharagpur
Kharagpur, West Bengal, India | PIN - 721302

See location in the Map
03222 282435
Mail: support@ndl.gov.in

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in