NDLI: A defective signal peptide in the maize high-lysine mutant floury 2.

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A defective signal peptide in the maize high-lysine mutant floury 2.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Coleman, C. E. Lopes, M. A. Boston, R. S. Gillikin, J. W. Larkins, B. A.
Description	Author Affiliation: Coleman CE ( Department of Plant Sciences, University of Arizona, Tucson 85721, USA.);
Abstract	The maize floury 2 (fl2) mutation enhances the lysine content of the grain, but the soft texture of the endosperm makes it unsuitable for commercial production. The mutant phenotype is linked with the appearance of a 24-kDa alpha-zein protein and increased synthesis of binding protein, both of which are associated with irregularly shaped protein bodies. We have cloned the gene encoding the 24-kDa protein and show that it is expressed as a 22-kDa alpha-zein with an uncleaved signal peptide. Comparison of the deduced N-terminal amino acid sequence of the 24-kDa alpha-zein protein with other alpha-zeins revealed an alanine to valine substitution at the C-terminal position of the signal peptide, a histidine insertion within the seventh alpha-helical repeat, and an alanine to threonine substitution with the same alpha-helical repeat of the protein. Structural defects associated with this alpha-zein explain many of the phenotypic effects of the fl2 mutation.
ISSN	00278424
e-ISSN	10916490
Journal	Proceedings of the National Academy of Sciences of the United States of America
Issue Number	15
Volume Number	92
Language	English
Publisher	National Academy of Sciences
Publisher Date	1995-08-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Lysine Mutation Protein Sorting Signals Genetics Zea Mays Zein Amino Acid Sequence Blotting, Southern Cloning, Molecular Electrophoresis, Gel, Two-Dimensional Genetic Linkage Molecular Sequence Data Polymorphism, Restriction Fragment Length Protein Precursors Protein Processing, Post-Translational Chemistry Sequence Analysis Sequence Homology, Amino Acid Comparative Study Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, Non-P.H.S. Research Support, U.S. Gov't, P.H.S. Multidisciplinary
Content Type	Text
Resource Type	Article
Subject	Multidisciplinary

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