NDLI: Schizophrenia susceptibility associated with interstitial deletions of chromosome 22q11.

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Schizophrenia susceptibility associated with interstitial deletions of chromosome 22q11.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Morrow, B. Wolyniec, P. S. Gos, A. Nestadt, G. Morris, M. A. Lasseter, V. K. Shprintzen, R. J. Goldberg, R. Borrow, J. Karayiorgou, M.
Description	Author Affiliation: Karayiorgou M ( Fred Hutchinson Cancer Research Center, Seattle, WA 98104, USA.);
Abstract	We report the results of two studies examining the genetic overlap between schizophrenia and velocardiofacial syndrome. In study A, we characterize two interstitial deletions identified on chromosome 22q11 in a sample of schizophrenic patients. The size of the deletions was estimated to be between 1.5 and 2 megabases. In study B, we examine whether variations in deletion size are associated with the schizophrenic phenotype in velocardiofacial syndrome patients. Our results show that a region of the genome that has been previously implicated by genetic linkage analysis can harbor genetic lesions that increase the susceptibility to schizophrenia. Our findings should facilitate identification and cloning of the schizophrenia susceptibility gene(s) in this region and identification of more homogeneous subgroups of patients.
ISSN	00278424
e-ISSN	10916490
Journal	Proceedings of the National Academy of Sciences of the United States of America
Issue Number	17
Volume Number	92
Language	English
Publisher	National Academy of Sciences
Publisher Date	1995-09-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Abnormalities, Multiple Genetics Chromosome Deletion Chromosomes, Human, Pair 22 Schizophrenia Adolescent Cell Line, Transformed Chromosome Mapping DNA Primers Genetic Markers Genetic Predisposition To Disease Herpesvirus 4, Human In Situ Hybridization, Fluorescence Lymphocytes Polymerase Chain Reaction Epidemiology Syndrome Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S. Multidisciplinary
Content Type	Text
Resource Type	Article
Subject	Multidisciplinary

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