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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Volkman, S. K. Wirth, D. F. Cowman, A. F. |
| Description | Author Affiliation: Volkman SK ( Department of Tropical Public Health, Harvard School of Public Health, Boston, MA 02115, USA.); |
| Abstract | The pfmdr1 gene has been associated with a drug-resistant phenotype in Plasmodium falciparum, and overexpression of pfmdr1 has been associated with mefloquine- and halofantrine-resistant parasites, but little is known about the functional role of pfmdr1 in this process. Here, we demonstrate that the pfmdr1 gene expressed in a heterologous yeast system functions as a transport molecule and complements a mutation in ste6, a gene which encodes a mating pheromone a-factor export molecule. In addition, the pfmdr1 gene containing two mutations which are associated with naturally occurring chloroquine resistance abolishes this mating phenotype, suggesting that these genetic polymorphisms alter this transport function. Our results support the functional role of pfmdr1 as a transport molecule in the mediation of drug resistance and provide an assay system to address the nature of this transport function. |
| ISSN | 00278424 |
| e-ISSN | 10916490 |
| Journal | Proceedings of the National Academy of Sciences of the United States of America |
| Issue Number | 19 |
| Volume Number | 92 |
| Language | English |
| Publisher | National Academy of Sciences |
| Publisher Date | 1995-10-01 |
| Publisher Place | United States |
| Access Restriction | Open |
| Subject Keyword | Chloroquine Pharmacology Genetic Complementation Test Glycoproteins P-Glycoprotein Genetics Plasmodium Falciparum Protozoan Proteins Saccharomyces Cerevisiae Proteins ATP-Binding Cassette Transporters Amino Acid Sequence Animals Biological Transport Blotting, Northern Drug Resistance Fluorescent Antibody Technique Fungal Proteins Genes, Fungal Genes, Protozoan Molecular Sequence Data Mutation Peptides Phenotype Pheromones Drug Effects Reproduction Saccharomyces Cerevisiae Sequence Analysis Sequence Homology, Amino Acid Comparative Study Research Support, U.S. Gov't, Non-P.H.S. Multidisciplinary |
| Content Type | Text |
| Resource Type | Article |
| Subject | Multidisciplinary |
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