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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Broccoli, D. Young, J. W. De Lange, T. |
| Description | Author Affiliation: Broccoli D ( Laboratory for Cell Biology and Genetics, Rockefeller University, New York, NY 10021, USA.); |
| Abstract | Bone marrow and peripheral blood leukocytes from 19 leukemia patients were found to contain telomerase activity detectable by a PCR-based assay. Telomerase was also detectable in nonmalignant bone marrow and peripheral blood leukocytes from normal donors, including fractions enriched for granulocytes, T lymphocytes, and monocytes/B cells. Semiquantitative comparison revealed considerable overlap between telomerase activities in samples from normal subjects and leukemia patients, confounding evaluation of the role of telomerase in this disease. These data indicate that human telomerase is not restricted to immortal cells and suggest that the somatic expression of this enzyme may be more widespread than was previously inferred from the decline of human telomeres. |
| ISSN | 00278424 |
| e-ISSN | 10916490 |
| Journal | Proceedings of the National Academy of Sciences of the United States of America |
| Issue Number | 20 |
| Volume Number | 92 |
| Language | English |
| Publisher | National Academy of Sciences |
| Publisher Date | 1995-10-01 |
| Publisher Place | United States |
| Access Restriction | Open |
| Subject Keyword | Granulocytes Enzymology Hematopoietic Stem Cells Leukemia Lymphocytes Telomerase Metabolism Acute Disease B-Lymphocytes Bone Marrow Pathology DNA Primers Kinetics Blood Leukemia, Myelogenous, Chronic, BCR-ABL Positive Molecular Sequence Data Polymerase Chain Reaction Reference Values Remission Induction T-Lymphocytes Comparative Study Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S. Multidisciplinary |
| Content Type | Text |
| Resource Type | Article |
| Subject | Multidisciplinary |
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