NDLI: An alternative pathway for signal flow from rod photoreceptors to ganglion cells in mammalian retina.

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An alternative pathway for signal flow from rod photoreceptors to ganglion cells in mammalian retina.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Baylor, D. A. Devries, S. H.
Description	Author Affiliation: DeVries SH ( Department of Neurobiology, Stanford University Medical School, CA 94305, USA.);
Abstract	Rod signals in the mammalian retina are thought to reach ganglion cells over the circuit rod-->rod depolarizing bipolar cell-->AII amacrine cell-->cone bipolar cells-->ganglion cells. A possible alternative pathway involves gap junctions linking the rods and cones, the circuit being rod-->cone-->cone bipolar cells-->ganglion cells. It is not clear whether this second pathway indeed relays rod signals to ganglion cells. We studied signal flow in the isolated rabbit retina with a multielectrode array, which allows the activity of many identified ganglion cells to be observed simultaneously while the preparation is stimulated with light and/or exposed to drugs. When transmission between rods and rod depolarizing bipolar cells was blocked by the glutamate agonist 2-amino-4-phosphonobutyric acid (APB), rod input to all On-center and briskly responding Off-center ganglion cells was dramatically reduced as expected. Off responses persisted, however, in Off-center sluggish and On-Off direction-selective ganglion cells. Presumably these responses were generated by the alternative pathway involving rod-cone junctions. This APB-resistant pathway may carry the major rod input to Off-center sluggish and On-Off direction-selective ganglion cells.
ISSN	00278424
e-ISSN	10916490
Journal	Proceedings of the National Academy of Sciences of the United States of America
Issue Number	23
Volume Number	92
Language	English
Publisher	National Academy of Sciences
Publisher Date	1995-12-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Cell Communication Retinal Ganglion Cells Physiology Retinal Rod Photoreceptor Cells Aminobutyrates Pharmacology Animals Dose-Response Relationship, Radiation Electrophysiology Excitatory Amino Acid Agonists In Vitro Techniques Models, Biological Rabbits Drug Effects Radiation Effects Vision, Ocular Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S. Multidisciplinary
Content Type	Text
Resource Type	Article
Subject	Multidisciplinary

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