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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Migone, T. S. Russell, S. M. Leonard, W. J. Friedmann, M. C. |
| Description | Author Affiliation: Friedmann MC ( Laboratory of Molecular Immunology, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892-1674, USA.); |
| Abstract | One of the earliest events induced by interleukin 2 (IL-2) is tyrosine phosphorylation of cellular proteins, including the IL-2 receptor beta chain (IL-2Rbeta). Simultaneous mutation of three tyrosines (Y338, Y392, and Y510) in the IL-2Rbeta cytoplasmic domain abrogated IL-2-induced proliferation, whereas mutation of only Y338 or of Y392 and Y510 inhibited proliferation only partially. While Y392 and Y510 were critical for IL-2-induced activation of signal transducers and activators of transcription (STAT proteins), Y338 was required for Shc-IL-2Rbeta association and for IL-2-induced tyrosine phosphorylation of Shc. Thus, activation of both Jak-STAT and Shc-coupled signaling pathways requires specific IL-2Rbeta tyrosines that together act in concert to mediate maximal proliferation. In COS-7 cells, overexpression of Jak1 augmented phosphorylation of Y338 as well as Y392 and Y510, suggesting that the role for this Jak kinase may extend beyond the Jak-STAT pathway. |
| ISSN | 00278424 |
| e-ISSN | 10916490 |
| Journal | Proceedings of the National Academy of Sciences of the United States of America |
| Issue Number | 5 |
| Volume Number | 93 |
| Language | English |
| Publisher | National Academy of Sciences |
| Publisher Date | 1996-09-01 |
| Publisher Place | United States |
| Access Restriction | Open |
| Subject Keyword | Adaptor Proteins, Signal Transducing Adaptor Proteins, Vesicular Transport Lymphocyte Activation Receptors, Interleukin-2 Physiology Signal Transduction T-Lymphocytes Amino Acid Sequence Animals Cells, Cultured Cercopithecus Aethiops DNA-Binding Proteins Metabolism Janus Kinase 1 Mice Molecular Sequence Data Mutagenesis, Site-Directed Phosphotyrosine Chemistry Protein Binding Protein-Tyrosine Kinases Proteins Receptor Aggregation STAT1 Transcription Factor Shc Signaling Adaptor Proteins Trans-Activators Tyrosine Research Support, Non-U.S. Gov't Multidisciplinary |
| Content Type | Text |
| Resource Type | Article |
| Subject | Multidisciplinary |
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