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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Wolfer, D. P. Collen, D. Zhuo, M. Huang, Y. Y. Lipp, H. P. Schoonjans, L. Godfraind, J. M. Mulligan, R. Kandel, E. R. Bach, M. E. Hawkins, R. D. Carmeliet, P. |
| Description | Author Affiliation: Huang YY ( Howard Hughes Medical Institute, Center for Neurobiology and Behavior, College of Physicians and Surgeons of Columbia University, New York, USA.); |
| Abstract | The gene encoding tissue-type plasminogen activator (t-PA) is an immediate response gene, downstream from CREB-1 and other constitutively expressed transcription factors, which is induced in the hippocampus during the late phase of long-term potentiation (L-LTP). Mice in which the t-PA gene has been ablated (t-PA-/-) showed no gross anatomical, electrophysiological, sensory, or motor abnormalities but manifest a selective reduction in L-LTP in hippocampal slices in both the Schaffer collateral-CA1 and mossy fiber-CA3 pathways. t-PA-/- mice also exhibit reduced potentiation by cAMP analogs and D1/D5 agonists. By contrast, hippocampal-dependent learning and memory were not affected in these mice, whereas performance was impaired on two-way active avoidance, a striatum-dependent task. These results provide genetic evidence that t-PA is a downstream effector gene important for L-LTP and show that modest impairment of L-LTP in CA1 and CA3 does not result in hippocampus-dependent behavioral phenotypes. |
| ISSN | 00278424 |
| e-ISSN | 10916490 |
| Journal | Proceedings of the National Academy of Sciences of the United States of America |
| Issue Number | 16 |
| Volume Number | 93 |
| Language | English |
| Publisher | National Academy of Sciences |
| Publisher Date | 1996-09-01 |
| Publisher Place | United States |
| Access Restriction | Open |
| Subject Keyword | Hippocampus Physiology Long-Term Potentiation Memory Tissue Plasminogen Activator Animals Avoidance Learning Behavior, Animal Conditioning (Psychology) In Vitro Techniques Mice Mice, Knockout Neural Pathways Neuronal Plasticity Space Perception Deficiency Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S. Multidisciplinary |
| Content Type | Text |
| Resource Type | Article |
| Subject | Multidisciplinary |
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