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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Mueckler, M. Vollenweider, P. Rose, D. W. Haruta, T. Gustafson, T. A. Nelson, J. G. Morris, A. J. Martin, S. S. Olefsky, J. M. |
| Description | Author Affiliation: Morris AJ ( Department of Medicine, University of California at San Diego, La Jolla 92093, USA.); |
| Abstract | Interaction of the activated insulin receptor (IR) with its substrate, insulin receptor substrate 1 (IRS-1), via the phosphotyrosine binding domain of IRS-1 and the NPXY motif centered at phosphotyrosine 960 of the IR, is important for IRS-1 phosphorylation. We investigated the role of this interaction in the insulin signaling pathway that stimulates glucose transport. Utilizing microinjection of competitive inhibitory reagents in 3T3-L1 adipocytes, we have found that disruption of the IR/IRS-1 interaction has no effect upon translocation of the insulin-responsive glucose transporter (GLUT4). The activity of these reagents was demonstrated by their ability to block insulin stimulation of two distinct insulin bioeffects, membrane ruffling and mitogenesis, in 3T3-L1 adipocytes and insulin-responsive rat 1 fibroblasts. These data suggest that phosphorylated IRS-1 is not an essential component of the metabolic insulin signaling pathway that leads to GLUT4 translocation, yet it appears to be required for other insulin bioeffects. |
| ISSN | 00278424 |
| e-ISSN | 10916490 |
| Journal | Proceedings of the National Academy of Sciences of the United States of America |
| Issue Number | 16 |
| Volume Number | 93 |
| Language | English |
| Publisher | National Academy of Sciences |
| Publisher Date | 1996-09-01 |
| Publisher Place | United States |
| Access Restriction | Open |
| Subject Keyword | Insulin Physiology Monosaccharide Transport Proteins Metabolism Muscle Proteins Phosphoproteins 3T3 Cells Adipocytes Amino Acid Sequence Animals Cell Compartmentation Cell Membrane Ultrastructure Glucose Transporter Type 4 Insulin Receptor Substrate Proteins Mice Microscopy, Fluorescence Mitosis Molecular Sequence Data Oligopeptides Chemistry Signal Transduction Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, Non-P.H.S. Research Support, U.S. Gov't, P.H.S. Multidisciplinary |
| Content Type | Text |
| Resource Type | Article |
| Subject | Multidisciplinary |
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