NDLI: cag, a pathogenicity island of Helicobacter pylori, encodes type I-specific and disease-associated virulence factors.

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cag, a pathogenicity island of Helicobacter pylori, encodes type I-specific and disease-associated virulence factors.

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cag, a pathogenicity island of Helicobacter pylori, encodes type I-specific and disease-associated virulence factors.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Lange, C. Xiang, Z. Rappuoli, R. Covacci, A. Crabtree, J. E. Ghiara, P. Censini, S. Borodovsky, M.
Description	Author Affiliation: Censini S ( Immunobiological Research Institute of Siena, Chiron Vaccines, Italy.);
Abstract	cagA, a gene that codes for an immunodominant antigen, is present only in Helicobacter pylori strains that are associated with severe forms of gastroduodenal disease (type I strains). We found that the genetic locus that contains cagA (cag) is part of a 40-kb DNA insertion that likely was acquired horizontally and integrated into the chromosomal glutamate racemase gene. This pathogenicity island is flanked by direct repeats of 31 bp. In some strains, cag is split into a right segment (cagI) and a left segment (cagII) by a novel insertion sequence (IS605). In a minority of H. pylori strains, cagI and cagII are separated by an intervening chromosomal sequence. Nucleotide sequencing of the 23,508 base pairs that form the cagI region and the extreme 3' end of the cagII region reveals the presence of 19 ORFs that code for proteins predicted to be mostly membrane associated with one gene (cagE), which is similar to the toxin-secretion gene of Bordetella pertussis, ptlC, and the transport systems required for plasmid transfer, including the virB4 gene of Agrobacterium tumefaciens. Transposon inactivation of several of the cagI genes abolishes induction of IL-8 expression in gastric epithelial cell lines. Thus, we believe the cag region may encode a novel H. pylori secretion system for the export of virulence determinants.
ISSN	00278424
e-ISSN	10916490
Journal	Proceedings of the National Academy of Sciences of the United States of America
Issue Number	25
Volume Number	93
Language	English
Publisher	National Academy of Sciences
Publisher Date	1996-01-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Antigens, Bacterial Genetics Bacterial Proteins Genes, Bacterial Helicobacter Pylori Chromosome Mapping Evolution, Molecular Pathogenicity Molecular Sequence Data Sequence Analysis Virulence Research Support, Non-U.S. Gov't Multidisciplinary
Content Type	Text
Resource Type	Article
Subject	Multidisciplinary

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