NDLI: The N-terminal propiece of interleukin 1 alpha is a transforming nuclear oncoprotein.

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The N-terminal propiece of interleukin 1 alpha is a transforming nuclear oncoprotein.

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The N-terminal propiece of interleukin 1 alpha is a transforming nuclear oncoprotein.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Lovett, D. H. Locksley, R. M. Turck, J. Stevenson, F. T.
Description	Author Affiliation: Stevenson FT ( Department of Medicine, University of California, Davis, Sacramento 95817, USA.);
Abstract	Interleukin 1 alpha (IL-1 alpha) is a pleiotropic cytokine involved in the immune response, inflammatory processes, and hematopoiesis, and acts as a mitogen for several malignant cell types, including acute leukemia and Kaposi sarcoma cells. These diverse activities have been exclusively attributed to the plasma membrane receptor-binding, 17-kDa C-terminal component (mature IL-1 alpha) that results from proteolytic processing of the 31- to 33-kDa precursor protein. No biologic function has been ascribed to the unusually large, 16-kDa N-terminal propiece formed as a result of proteolytic processing of IL-1 alpha. We report that the IL-1 alpha N-terminal propiece is concentrated by means of a nuclear localization sequence within the nuclei of both transfected and leukemic cell lines. Overexpression of this component in glomerular mesangial cells, a model perivascular myofibroblast cell type capable of IL-1 alpha synthesis and processing, results in malignant transformation to a spindle cell-type tumor. The functionally bipartite nature of the IL-1 alpha precursor represents a unique combination of the C-terminal, classical cytokine and an N-terminal nuclear oncoprotein. These findings suggest that nuclear transport of the IL-1 alpha N-terminal component may represent a critical component in the transformation of IL-1 alpha-producing cells in the bone marrow or the perivascular area to a malignant phenotype.
ISSN	00278424
e-ISSN	10916490
Journal	Proceedings of the National Academy of Sciences of the United States of America
Issue Number	2
Volume Number	94
Language	English
Publisher	National Academy of Sciences
Publisher Date	1997-03-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Interleukin-1 Chemistry Nuclear Proteins Physiology Proto-Oncogene Proteins Amino Acid Sequence Animals Cell Compartmentation Cytosol Metabolism Fluorescent Antibody Technique, Indirect Kidney Glomerulus Molecular Sequence Data Peptide Fragments Research Support, U.S. Gov't, Non-P.H.S. Research Support, U.S. Gov't, P.H.S. Multidisciplinary
Content Type	Text
Resource Type	Article
Subject	Multidisciplinary

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