NDLI: DNA methylation and genetic instability in colorectal cancer cells.

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The objects of selection.

The Alzheimer family of diseases: many etiologies, one pathogenesis?

Pax-6: where to be conserved is not conservative.

Bronchial asthma: lessons from murine models.

Altered DNA methylation and genome instability: a new pathway to cancer?

Virtual combinatorial libraries: dynamic generation of molecular and supramolecular diversity by self-assembly.

Transgenic elite indica rice plants expressing CryIAc delta-endotoxin of Bacillus thuringiensis are resistant against yellow stem borer (Scirpophaga incertulas).

Removal of a cryptic intron and subcellular localization of green fluorescent protein are required to mark transgenic Arabidopsis plants brightly.

Generation of cDNA expression libraries enriched for in-frame sequences.

Identification of a functional water channel in cytochrome P450 enzymes.

Structural features of the binding site for ribosomal protein S8 in Escherichia coli 16S rRNA defined using NMR spectroscopy.

From phosphatases to vanadium peroxidases: a similar architecture of the active site.

Discovery and analysis of inflammatory disease-related genes using cDNA microarrays.

The von Hippel-Lindau tumor-suppressor gene product forms a stable complex with human CUL-2, a member of the Cdc53 family of proteins.

Nucleoprotein-based nanoscale assembly.

Cell cycle-dependent phosphorylation of mammalian protein phosphatase 1 by cdc2 kinase.

Supercoil-induced extrusion of a regulatory DNA hairpin.

Receptor and G betagamma isoform-specific interactions with G protein-coupled receptor kinases.

Silent information regulator protein complexes in Saccharomyces cerevisiae: a SIR2/SIR4 complex and evidence for a regulatory domain in SIR4 that inhibits its interaction with SIR3.

Evidence for a lipochaperonin: association of active protein-folding GroESL oligomers with lipids can stabilize membranes under heat shock conditions.

Identification of an alternative form of human lactoferrin mRNA that is expressed differentially in normal tissues and tumor-derived cell lines.

A putative angiogenin receptor in angiogenin-responsive human endothelial cells.

Volatile signals of the major histocompatibility complex in male mouse urine.

DNA damage can alter the stability of nucleosomes: effects are dependent on damage type.

Regulation of E2F through ubiquitin-proteasome-dependent degradation: stabilization by the pRB tumor suppressor protein.

Identification of a novel negative retinoic acid responsive element in the promoter of the human matrix Gla protein gene.

Coordination dynamics of biological zinc 'clusters' in metallothioneins and in the DNA-binding domain of the transcription factor Gal4.

Molecular characterization of human and mouse fatty acid amide hydrolases.

Sequence requirements of the HIV-1 protease flap region determined by saturation mutagenesis and kinetic analysis of flap mutants.

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UV-induced mutagenesis of human p53 in a vector replicated in Saccharomyces cerevisiae.

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Coexpression of nuclear receptor partners increases their solubility and biological activities.

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Aberrant trafficking of hepatitis B virus glycoproteins in cells in which N-glycan processing is inhibited.

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Generation of NK1.1+ T cell antigen receptor alpha/beta+ thymocytes associated with intact thymic structure.

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DNA methylation and genetic instability in colorectal cancer cells.

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Oxytocin stimulates the release of luteinizing hormone-releasing hormone from medial basal hypothalamic explants by releasing nitric oxide.

Early mortality surge in protein-deprived females causes reversal of sex differential of life expectancy in Mediterranean fruit flies.

Severe spatial navigation deficit in the Morris water maze after single high dose of neonatal x-ray irradiation in the rat.

Membrane permeabilization by Listeria monocytogenes phosphatidylinositol-specific phospholipase C is independent of phospholipid hydrolysis and cooperative with listeriolysin O. (Journal: Proceedings of the National Academy of Sciences of the United States of America Volume: 94 Issue: 6)

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DNA methylation and genetic instability in colorectal cancer cells.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Lengauer, C. Vogelstein, B. Kinzler, K. W.
Description	Author Affiliation: Lengauer C ( Howard Hughes Medical Institute at The Johns Hopkins Oncology Center, Baltimore, MD 21231, USA.);
Abstract	Apparent alterations in DNA methylation have been observed in many cancers, but whether such alterations represent a persistent alteration in the normal methylation process is not known. In this study, we report a striking difference in the expression of exogenously introduced retroviral genes in various colorectal cancer cell lines. Extinguished expression was associated with DNA methylation and could be reversed by treatment with the demethylating agent 5-azacytidine. A striking correlation between genetic instability and methylation capacity suggested that methylation abnormalities may play a role in chromosome segregation processes in cancer cells.
ISSN	00278424
e-ISSN	10916490
Journal	Proceedings of the National Academy of Sciences of the United States of America
Issue Number	6
Volume Number	94
Language	English
Publisher	National Academy of Sciences
Publisher Date	1997-04-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Colorectal Neoplasms Genetics DNA Methylation Azacitidine Pharmacology Cell Line DNA, Neoplasm Chemistry Drug Effects Metabolism Genes, Viral Kanamycin Kinase Molecular Sequence Data Phosphotransferases (Alcohol Group Acceptor) Biosynthesis Polymerase Chain Reaction Protein Biosynthesis Recombinant Proteins Repetitive Sequences, Nucleic Acid Retroviridae Transcription, Genetic Transfection Tumor Cells, Cultured Beta-Galactosidase Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S. Multidisciplinary
Content Type	Text
Resource Type	Article
Subject	Multidisciplinary

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