NDLI: Impairment of antigen-specific antibody production in transgenic mice expressing a dominant-negative form of gp130.

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Impairment of antigen-specific antibody production in transgenic mice expressing a dominant-negative form of gp130.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Marukawa, S. Yasui, T. Yoshida, K. Kumanogoh, T. Hirota, H. Taga, T. Kumanogoh, A. Kishimoto, T. Lee, I. S.
Description	Author Affiliation: Kumanogoh A ( Department of Medicine III, Osaka University Medical School, Yamada-oka, Suita, Japan.);
Abstract	gp130 is a common signal-transducing receptor component for the interleukin 6 family of cytokines functioning in, for example, immune, hematopoietic, and nervous systems. In this study, to investigate the physiological functions of gp130 and to determine the pathological consequences of impaired gp130 signals, we have generated transgenic mice expressing a cytoplasmically truncated form of mouse gp130. Expression of this form of gp130 in lymphocytes significantly suppressed interleukin 6-induced tyrosine phosphorylation of endogenous gp130 and a downstream signaling molecule, signal transducer and activator of transcription 3, indicating that this form has a dominant negative function. In spite of the impaired gp130 signals, the development of lymphocytes in the transgenic mice appeared normal in terms of surface marker phenotypes. These mice, however, exhibited severe defects in antigen-specific antibody production of most immunoglobulin isotypes other than IgM after immunization with 2,4-dinitrophenol-conjugated ovalbumin. These results demonstrate in vivo that gp130 is essential for antigen-specific antibody production.
ISSN	00278424
e-ISSN	10916490
Journal	Proceedings of the National Academy of Sciences of the United States of America
Issue Number	6
Volume Number	94
Language	English
Publisher	National Academy of Sciences
Publisher Date	1997-04-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Antibody Formation Antigens, CD Biosynthesis Genetics B-Lymphocytes Immunology Membrane Glycoproteins T-Lymphocytes Actins Animals Drug Effects Metabolism Cytokine Receptor Gp130 DNA-Binding Proteins Dinitrophenols Genes, Dominant Haptens Interleukin-6 Pharmacology Mice Mice, Inbred C57BL Mice, Transgenic Ovalbumin Phosphorylation Promoter Regions, Genetic STAT3 Transcription Factor Signal Transduction Spleen Thymus Gland Trans-Activators Research Support, Non-U.S. Gov't Multidisciplinary
Content Type	Text
Resource Type	Article
Subject	Multidisciplinary

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