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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Martin, G. S. Aftab, D. T. Kwan, J. |
| Description | Author Affiliation: Aftab DT ( Department of Molecular and Cell Biology, University of California, Berkeley 94720-3204, USA.); |
| Abstract | Signaling by a variety of receptor and nonreceptor tyrosine kinases is mediated by Ras, a membrane-associated GTPase. Expression of v-Src, a transforming nonreceptor tyrosine kinase, results in Ras activation, and inhibition of Ras function in NIH 3T3 cells suppresses transformation by v-Src, indicating that in these cells Ras-dependent signaling pathways are required for v-Src to exert its biological effects. However, we show here that Ras was not activated in Rat-2 fibroblasts transformed by wild-type v-Src, or in chicken embryo fibroblasts transformed by SRX5, a v-Src mutant with a linker insertion at the major site of autophosphorylation. Expression of a dominant-negative mutant of Ras completely inhibited the ability of v-Src to activate the mitogen-activated protein kinase ERK2, which is downstream of Ras. However, dominant-negative Ras did not suppress transformation by v-Src as judged by a variety of criteria. Thus, v-Src can transform at least some cell types in the absence of Ras activation or Ras-stimulated ERK2 activity, and in these cells activation of Ras-independent signaling pathways must therefore be sufficient for transformation. |
| ISSN | 00278424 |
| e-ISSN | 10916490 |
| Journal | Proceedings of the National Academy of Sciences of the United States of America |
| Issue Number | 7 |
| Volume Number | 94 |
| Language | English |
| Publisher | National Academy of Sciences |
| Publisher Date | 1997-05-01 |
| Publisher Place | United States |
| Access Restriction | Open |
| Subject Keyword | Oncogene Protein P21(ras) Metabolism Oncogene Protein Pp60(v-src) Physiology Animals Calcium-Calmodulin-Dependent Protein Kinases Antagonists & Inhibitors Cell Line, Transformed Chick Embryo Enzyme Activation Genes, Dominant Mitogen-Activated Protein Kinase 1 Genetics Phosphorylation Signal Transduction Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S. Multidisciplinary |
| Content Type | Text |
| Resource Type | Article |
| Subject | Multidisciplinary |
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