NDLI: Differential display of genome subsets containing specific interspersed repeats.

Please wait, while we are loading the content...

Year: 2017 Volume: 114

Year: 2016 Volume: 113

Year: 2015 Volume: 112

Year: 2014 Volume: 111

Year: 2013 Volume: 110

Year: 2012 Volume: 109

Year: 2011 Volume: 108

Year: 2010 Volume: 107

Year: 2009 Volume: 106

Year: 2008 Volume: 105

Year: 2007 Volume: 104

Year: 2006 Volume: 103

Year: 2005 Volume: 102

Year: 2004 Volume: 101

Year: 2003 Volume: 100

Year: 2002 Volume: 99

Year: 2001 Volume: 98

Year: 2000 Volume: 97

Year: 1999 Volume: 96

Year: 1998 Volume: 95

Year: 1997 Volume: 94

Year: 1997 Volume: 94 Issue: 26

Year: 1997 Volume: 94 Issue: 25

Year: 1997 Volume: 94 Issue: 24

Year: 1997 Volume: 94 Issue: 23

Year: 1997 Volume: 94 Issue: 22

Year: 1997 Volume: 94 Issue: 21

Year: 1997 Volume: 94 Issue: 20

Year: 1997 Volume: 94 Issue: 19

Year: 1997 Volume: 94 Issue: 18

Year: 1997 Volume: 94 Issue: 17

Year: 1997 Volume: 94 Issue: 16

Year: 1997 Volume: 94 Issue: 15

Year: 1997 Volume: 94 Issue: 14

Year: 1997 Volume: 94 Issue: 13

Year: 1997 Volume: 94 Issue: 12

Year: 1997 Volume: 94 Issue: 11

Year: 1997 Volume: 94 Issue: 10

Year: 1997 Volume: 94 Issue: 9

The role of viruses in the etiology of cancer and leukemia in animals and in humans.

Regulation of gene expression and its role in long-term memory and synaptic plasticity.

Leptin expression and action: new experimental paradigms.

Effects of folding on metalloprotein active sites.

The crystal structure of subtilisin Carlsberg in anhydrous dioxane and its comparison with those in water and acetonitrile

Noninvasive assessment of the developing Xenopus cardiovascular system using optical coherence tomography.

A general purpose RNA-cleaving DNA enzyme

DNA looping by Ku and the DNA-dependent protein kinase.

A novel bHLH-PAS factor with close sequence similarity to hypoxia-inducible factor 1α regulates the VEGF expression and is potentially involved in lung and vascular development

RhoGDIgamma: a GDP-dissociation inhibitor for Rho proteins with preferential expression in brain and pancreas.

Is strong hydrogen bonding in the transition state enough to account for the observed rate acceleration in a mutant of papain?

Gene induction in response to unfolded protein in the endoplasmic reticulum is mediated through Ire1p kinase interaction with a transcriptional coactivator complex containing Ada5p.

Microperoxidase/H2O2-mediated alkoxylating dehalogenation of halophenol derivatives in alcoholic media.

Obese gene expression at in vivo levels by fat pads derived from s.c. implanted 3T3-F442A preadipocytes.

Reduced RNA polymerase II transcription in intact and permeabilized Cockayne syndrome group B cells.

Hypolipidemic drugs, polyunsaturated fatty acids, and eicosanoids are ligands for peroxisome proliferator-activated receptors alpha and delta.

Fatty acids and eicosanoids regulate gene expression through direct interactions with peroxisome proliferator-activated receptors alpha and gamma.

Insertional editing of nascent mitochondrial RNAs in Physarum.

P110delta, a novel phosphoinositide 3-kinase in leukocytes.

Bacterial nodulation protein NodZ is a chitin oligosaccharide fucosyltransferase which can also recognize related substrates of animal origin.

Identification of ERF-1 as a member of the AP2 transcription factor family.

Cytoplasmic sequestration of an O6-methylguanine-DNA methyltransferase enhancer binding protein in DNA repair-deficient human cells.

Purification and characterization of a human RNA adenosine deaminase for glutamate receptor B pre-mRNA editing.

Regulation of insulin preRNA splicing by glucose.

The rational design of allosteric interactions in a monomeric protein and its applications to the construction of biosensors.

Modulation of glucose responsiveness of insulinoma beta-cells by graded overexpression of glucokinase.

Dynamic electron microscopy of ATP-induced myosin head movement in living muscle thick filaments.

The conformation of NAD+ bound to lactate dehydrogenase determined by nuclear magnetic resonance with suppression of spin diffusion.

Charge separation in the reaction center of photosystem II studied as a function of temperature.

Kinetics of force generation by single kinesin molecules activated by laser photolysis of caged ATP.

Functional and idling rotatory motion within F1-ATPase.

Rescue of cardiac alpha-actin-deficient mice by enteric smooth muscle gamma-actin.

The bovine papillomavirus E6 oncoprotein interacts with paxillin and disrupts the actin cytoskeleton.

Direct and GTP-dependent interaction of ADP ribosylation factor 1 with coatomer subunit beta.

Intracellular activation of gelatinase A (72-kDa type IV collagenase) by normal fibroblasts.

Reversible antisense inhibition of Shaker-like Kv1.1 potassium channel expression impairs associative memory in mouse and rat.

Inositol hexakisphosphate stimulates non-Ca2+-mediated and primes Ca2+-mediated exocytosis of insulin by activation of protein kinase C.

Cloning and characterization of a putative human serine/threonine protein kinase transcriptionally modified during anisotonic and isotonic alterations of cell volume.

The nuclear matrix revealed by eluting chromatin from a cross-linked nucleus.

Cloning and characterization of human karyopherin beta3.

Transport of a novel complex in the cytoplasmic matrix of Chlamydomonas flagella

Two active states of the Ras-related Bud1/Rsr1 protein bind to different effectors to determine yeast cell polarity.

A 60-kDa plant microtubule-associated protein promotes the growth and stabilization of neurotubules in vitro.

A fibroblast cell line defective in alkyl-dihydroxyacetone phosphate synthase: a novel defect in plasmalogen biosynthesis.

Transcriptional coactivator cAMP response element binding protein mediates induction of the human proliferating cell nuclear antigen promoter by the adenovirus E1A oncoprotein.

GATA-1 transcription is controlled by distinct regulatory mechanisms during primitive and definitive erythropoiesis.

Expression of mutated Nck SH2/SH3 adaptor respecifies mesodermal cell fate in Xenopus laevis development

Transport and fate of trifluoroacetate in upland forest and wetland ecosystems.

Directed evolution of a fucosidase from a galactosidase by DNA shuffling and screening.

Independent, specialized invasions of ectomycorrhizal mutualism by two nonphotosynthetic orchids.

An apportionment of human DNA diversity.

The origin of red algae: implications for plastid evolution.

Mutations in mitochondrial cytochrome c oxidase genes segregate with late-onset Alzheimer disease

A hepatic lipase (LIPC) allele associated with high plasma concentrations of high density lipoprotein cholesterol.

Overexpression of a truncated human topoisomerase III partially corrects multiple aspects of the ataxia-telangiectasia phenotype.

The muscle of lawrence in Drosophila: a case of repeated evolutionary loss.

Differential display of genome subsets containing specific interspersed repeats.

Defective 'pacemaker' current (Ih) in a zebrafish mutant with a slow heart rate.

Double mutagenesis of a positive charge cluster in the ligand-binding site of the ferric enterobactin receptor, FepA.

Synergism between hypersensitive sites confers long-range gene activation by the β-globin locus control region

Genotype determining low catechol-O-methyltransferase activity as a risk factor for obsessive-compulsive disorder.

Carcinogens induce reversion of the mouse pink-eyed unstable mutation.

A steroid-triggered switch in E74 transcription factor isoforms regulates the timing of secondary-response gene expression.

A variable domain of delayed replication in FRAXA fragile X chromosomes: X inactivation-like spread of late replication.

A novel chimeric Ig heavy chain from a teleost fish shares similarities to IgD.

Abnormal T cell selection on nod thymic epithelium is sufficient to induce autoimmune manifestations in C57BL/6 athymic nude mice.

Self and viral peptides can initiate lysis by autologous natural killer cells

A cholera toxoid-insulin conjugate as an oral vaccine against spontaneous autoimmune diabetes.

LARD: a new lymphoid-specific death domain containing receptor regulated by alternative pre-mRNA splicing.

Modulation of murine systemic lupus erythematosus with peptides based on complementarity determining regions of a pathogenic anti-DNA monoclonal antibody.

Biochemical characterization and crystalization of human Zn-alpha2-glycoprotein, a soluble class I major histocompatibility complex homolog.

Peptide-specific killing of antigen-presenting cells by a recombinant antibody-toxin fusion protein targeted to major histocompatibility complex/peptide class I complexes with T cell receptor-like specificity.

Direct antidiabetic effect of leptin through triglyceride depletion of tissues.

T and B lymphocytes play a minor role in atherosclerotic plaque formation in the apolipoprotein E-deficient mouse.

Increased atherosclerosis in mice reconstituted with apolipoprotein E null macrophages.

A new reporter cell line to monitor HIV infection and drug susceptibility in vitro.

A transgenic mouse model for measles virus infection of the brain.

Ultrarapid, highly efficient viral gene transfer to the heart.

Thrombin cleaves recombinant human thrombopoietin: one of the proteolytic events that generates truncated forms of thrombopoietin.

A proline-rich motif in p53 is required for transactivation-independent growth arrest as induced by Gas1.

Mutagenicity of 5-aza-2'-deoxycytidine is mediated by the mammalian DNA methyltransferase.

Transient immunomodulation with anti-CD40 ligand antibody and CTLA4Ig enhances persistence and secondary adenovirus-mediated gene transfer into mouse liver.

Regulation of the expression of the tissue transglutaminase gene by DNA methylation.

Cytokine manipulation of primitive human hematopoietic cell self-renewal.

Fertilization antigen-1: cDNA cloning, testis-specific expression, and immunocontraceptive effects.

Ras-dependent pathways induce obstructive hypertrophy in echo-selected transgenic mice.

Transient and selectable transformation of the parasitic protist Trichomonas vaginalis.

Bipolar localization of a chromosome partition protein in Bacillus subtilis.

Localization of guanylate cyclase-activating protein 2 in mammalian retinas.

Human tau becomes phosphorylated and forms filamentous deposits when overexpressed in lamprey central neurons in situ.

The regulator of early gliogenesis glial cells missing is a transcription factor with a novel type of DNA-binding domain.

Repair of plasmalemmal lesions by vesicles

Calpain activity promotes the sealing of severed giant axons.

The antibipolar drug valproate mimics lithium in stimulating glutamate release and inositol 1,4,5-trisphosphate accumulation in brain cortex slices but not accumulation of inositol monophosphates and bisphosphates.

Rescuing impairment of long-term potentiation in fyn-deficient mice by introducing Fyn transgene.

Olfaction: transient expression of a putative odorant receptor in the avian notochord.

Insulin-like growth factor I protects and rescues hippocampal neurons against beta-amyloid- and human amylin-induced toxicity.

Cell death prevention, mitogen-activated protein kinase stimulation, and increased sulfatide concentrations in Schwann cells and oligodendrocytes by prosaposin and prosaptides.

Insulin secretion is regulated by the glucose-dependent production of islet beta cell macrophage migration inhibitory factor.

Increased substance P responses in dorsal root ganglia and intestinal macrophages during Clostridium difficile toxin A enteritis in rats.

A membrane-anchored E-type endo-1,4-beta-glucanase is localized on Golgi and plasma membranes of higher plants.

Elicitor-stimulated ion fluxes and $O_{2}^{−}$ from the oxidative burst are essential components in triggering defense gene activation and phytoalexin synthesis in parsley

Molecular basis of plant-specific acid activation of $K^{+}$ uptake channels

Evolution of the primate lineage leading to modern humans: phylogenetic and demographic inferences from DNA sequences.

Year: 1997 Volume: 94 Issue: 8

Year: 1997 Volume: 94 Issue: 7

Year: 1997 Volume: 94 Issue: 6

Year: 1997 Volume: 94 Issue: 5

Year: 1997 Volume: 94 Issue: 4

Year: 1997 Volume: 94 Issue: 3

Year: 1997 Volume: 94 Issue: 2

Year: 1997 Volume: 94 Issue: 1

Year: 1996 Volume: 93

Year: 1995 Volume: 92

Year: 1994 Volume: 91

Year: 1993 Volume: 90

Year: 1992 Volume: 89

Year: 1991 Volume: 88

Year: 1990 Volume: 87

Year: 1989 Volume: 86

Year: 1988 Volume: 85

Year: 1987 Volume: 84

Year: 1986 Volume: 83

Year: 1985 Volume: 82

Year: 1984 Volume: 81

Year: 1983 Volume: 80

Year: 1982 Volume: 79

Year: 1981 Volume: 78

Year: 1980 Volume: 77

Year: 1979 Volume: 76

Year: 1978 Volume: 75

Year: 1977 Volume: 74

Year: 1976 Volume: 73

Year: 1975 Volume: 72

Year: 1974 Volume: 71

Year: 1973 Volume: 70

Year: 1972 Volume: 69

Year: 1971 Volume: 68

Year: 1970 Volume: 67

Year: 1970 Volume: 66

Year: 1970 Volume: 65

Year: 1969 Volume: 64

Year: 1969 Volume: 63

Year: 1969 Volume: 62

Year: 1968 Volume: 61

Year: 1968 Volume: 60

Year: 1968 Volume: 59

Year: 1967 Volume: 58

Year: 1967 Volume: 57

Year: 1966 Volume: 56

Year: 1966 Volume: 55

Differential display of genome subsets containing specific interspersed repeats.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Chandra, A. Broude, N. E. Smith, C. L.
Description	Author Affiliation: Broude NE ( Department of Biomedical Engineering, Boston University, 36 Cummington Street, Boston, MA 02215, USA.);
Abstract	A genomic differential display method was developed that analyzes many restriction fragment length polymorphisms simultaneously. Interspersed repeat sequences were used to reduce DNA sample complexity and to target genomic subsets of interest. This work focused on trinucleotide repeats because of their importance in human inherited diseases. Immobilized repeat-containing oligonucleotides were used to capture genomic DNA fragments containing sequences complementary to the oligonucleotide. Captured fragments were amplified by PCR and fluorescently labeled using primers complementary to the repeat sequence and/or to the known sequences ligated to the ends of the restriction fragments. The labeled PCR fragments were displayed by size on a high-resolution automated fluorescent DNA sequencing instrument. Although there was a conservation in the overall pattern of displayed genome subsets, many clear and reproducible differences were detected when genomes from different individuals were compared. Fewer differences were detected within, than between, monozygotic twin pair genomes. In control experiments, the method distinguished between Huntington disease alleles with normal and expanded CAG repeat lengths.
ISSN	00278424
e-ISSN	10916490
Journal	Proceedings of the National Academy of Sciences of the United States of America
Issue Number	9
Volume Number	94
Language	English
Publisher	National Academy of Sciences
Publisher Date	1997-05-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Genome, Human Huntington Disease Genetics Polymerase Chain Reaction Polymorphism, Restriction Fragment Length Trinucleotide Repeats Molecular Sequence Data Twins, Monozygotic Research Support, U.S. Gov't, Non-P.H.S. Multidisciplinary
Content Type	Text
Resource Type	Article
Subject	Multidisciplinary

Central Library (ISO-9001:2015 Certified)
Indian Institute of Technology Kharagpur
Kharagpur, West Bengal, India | PIN - 721302

See location in the Map
03222 282435
Mail: support@ndl.gov.in

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in