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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Terpstra, V. Kondratenko, N. Steinberg, D. |
| Description | Author Affiliation: Terpstra V ( Department of Medicine, University of California at San Diego, 9500 Gilman Drive, La Jolla, CA 92093-0682, USA.); |
| Abstract | Macrophage binding of oxidatively damaged red blood cells (OxRBC) and apoptotic thymocytes correlates in many instances with a loss of phospholipid bilayer asymmetry, i.e., with an increase in expression of phosphatidylserine on the outer leaflet of the plasma membrane. Oxidatively modified LDL (OxLDL) can compete for the binding of these ligands to macrophages. However, the receptor(s) responsible remains to be identified. The present studies show that mouse peritoneal macrophages totally lacking scavenger receptor A (SRA) bound OxRBC just as effectively as wild-type macrophages, whereas their binding and uptake of acetyl LDL was reduced by more than 80%. Binding of apoptotic thymocytes and binding of OxLDL were also reduced, but only by 20-30%. We conclude that SRA is not involved in the recognition of phosphatidylserine-rich membranes but contributes to the binding of OxLDL and apoptotic thymocytes. The binding of OxRBC was almost totally calcium-dependent, whereas the binding of apoptotic thymocytes was not, suggesting that the mechanisms involved in their uptake by macrophages under these conditions were different. |
| ISSN | 00278424 |
| e-ISSN | 10916490 |
| Journal | Proceedings of the National Academy of Sciences of the United States of America |
| Issue Number | 15 |
| Volume Number | 94 |
| Language | English |
| Publisher | National Academy of Sciences |
| Publisher Date | 1997-08-01 |
| Publisher Place | United States |
| Access Restriction | Open |
| Subject Keyword | Erythrocytes Cytology Lipoproteins, LDL Metabolism Macrophages, Peritoneal Membrane Proteins Oxidative Stress Receptors, Immunologic Genetics Receptors, Lipoprotein Thymus Gland Animals Cells, Cultured Mice Mice, Knockout Receptors, Scavenger Scavenger Receptors, Class B Sequence Deletion Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S. Multidisciplinary |
| Content Type | Text |
| Resource Type | Article |
| Subject | Multidisciplinary |
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