NDLI: Marked decrease of neuropeptide Y Y2 receptor binding sites in the hippocampus in murine prion disease.

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Marked decrease of neuropeptide Y Y2 receptor binding sites in the hippocampus in murine prion disease.

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Marked decrease of neuropeptide Y Y2 receptor binding sites in the hippocampus in murine prion disease.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Dearmond, S. J. Prusiner, S. B. Groth, D. Diez, M. Hökfelt, T. Koistinaho, J.
Description	Author Affiliation: Diez M ( Department of Neuroscience, Karolinska Institutet, Stockholm, Sweden.);
Abstract	Using autoradiographic binding methodology with monoiodinated peptide YY together with the agonists neuropeptide Y (NPY) and NPY (13-36), as well as in situ hybridization with oligonucleotide probes complementary to the NPY Y2 receptor (Y2-R) mRNA, we have studied whether or not intracerebral prion inoculation affects Y2-Rs in male CD-1 mice. Monoiodinated peptide YY binding, mainly representing Y2-Rs, was down-regulated by 85% in the CA1 strata oriens and radiatum and by 50-65% in the CA3 stratum oriens 110-140 days postinoculation. In the CA3 stratum radiatum, where the mossy fibers from the dentate granule cells project, there was a significant decrease in PYY binding at 110-120 days. Y2-R mRNA, moderately expressed both in the CA1 and CA3 pyramidal cell layers and the granule cell layer in the dentate gyrus, showed a slight, but not significant, decrease in CA3 neurons 130 days postinoculation. The results indicate that the accumulation of the scrapie prion protein in the CA1-3 region strongly inhibits NPY binding at the Y2-Rs, which, however, is only marginally due to reduced Y2-R mRNA expression. The loss of the ability of NPY to bind to inhibitory Y2-Rs may cause dysfunction of hippocampal circuits and may contribute to the clinical symptoms in mouse scrapie.
ISSN	00278424
e-ISSN	10916490
Journal	Proceedings of the National Academy of Sciences of the United States of America
Issue Number	24
Volume Number	94
Language	English
Publisher	National Academy of Sciences
Publisher Date	1997-01-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Hippocampus Metabolism Receptors, Neuropeptide Y Scrapie Animals Autoradiography Binding Sites In Situ Hybridization Mice Neuropeptide Y RNA, Messenger Genetics Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S. Multidisciplinary
Content Type	Text
Resource Type	Article
Subject	Multidisciplinary

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