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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Goldstein, R. E. Cox, E. C. Franke, J. Kessin, R. H. Pálsson, E. Lee, K. J. |
| Description | Author Affiliation: Pálsson E ( Department of Molecular Biology, Princeton University, Princeton, NJ 08544, USA.); |
| Abstract | Starving Dictyostelium amoebae emit pulses of the chemoattractant cAMP that are relayed from cell to cell as circular and spiral waves. We have recently modeled spiral wave formation in Dictyostelium. Our model suggests that a secreted protein inhibitor of an extracellular cAMP phosphodiesterase selects for spirals. Herein we test the essential features of this prediction by comparing wave propagation in wild type and inhibitor mutants. We find that mutants rarely form spirals. The territory size of mutant strains is approximately 50 times smaller than wild type, and the mature fruiting bodies are smaller but otherwise normal. These results identify a mechanism for selecting one wave symmetry over another in an excitable system and suggest that the phosphodiesterase inhibitor may be under selection because it helps regulate territory size. |
| ISSN | 00278424 |
| e-ISSN | 10916490 |
| Journal | Proceedings of the National Academy of Sciences of the United States of America |
| Issue Number | 25 |
| Volume Number | 94 |
| Language | English |
| Publisher | National Academy of Sciences |
| Publisher Date | 1997-01-01 |
| Publisher Place | United States |
| Access Restriction | Open |
| Subject Keyword | Dictyostelium Cytology Physiology 3',5'-Cyclic-AMP Phosphodiesterases Antagonists & Inhibitors Animals Computer Simulation Cyclic AMP Genetics Enzyme Inhibitors Metabolism Models, Biological Movement Mutation Signal Transduction Comparative Study Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, Non-P.H.S. Research Support, U.S. Gov't, P.H.S. Multidisciplinary |
| Content Type | Text |
| Resource Type | Article |
| Subject | Multidisciplinary |
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